Recent advances in renal hypoxia: insights from bench experiments and computer simulations

The availability of oxygen in renal tissue is determined by the complex interactions among a host of processes, including renal blood flow, glomerular filtration, arterial-to-venous oxygen shunting, medullary architecture, Na(+) transport, and oxygen consumption. When this delicate balance is disrup...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology. Renal physiology 2016-07, Vol.311 (1), p.F162-F165
Main Author: Layton, Anita T
Format: Article
Language:English
Subjects:
Acute Kidney Injury - pathology
Animals
Blood pressure
Computer Simulation
Humans
Hypoxia
Hypoxia - pathology
Kidney diseases
Kidney Diseases - pathology
Nephrology
Oxygen
Oxygen Consumption
Pathology
Physiology
Renal Insufficiency, Chronic - pathology
Reviews
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The availability of oxygen in renal tissue is determined by the complex interactions among a host of processes, including renal blood flow, glomerular filtration, arterial-to-venous oxygen shunting, medullary architecture, Na(+) transport, and oxygen consumption. When this delicate balance is disrupted, the kidney may become susceptible to hypoxic injury. Indeed, renal hypoxia has been implicated as one of the major causes of acute kidney injury and chronic kidney diseases. This review highlights recent advances in our understanding of renal hypoxia; some of these studies were published in response to a recent Call for Papers of this journal: Renal Hypoxia.
ISSN:1931-857X
1522-1466
DOI:10.1152/ajprenal.00228.2016