Loading…
Evaluation of pharmacological activity of Hibiscus tiliaceus
Hibiscus tiliaceus , locally known as Bhola was examined for phytochemical properties and its cytotoxic, antibacterial, analgesic and neuropharmacological activities using the ethanol extract of leaf and bark. The phytochemical analysis of the leaf extract indicated the presence of tannins, whereas...
Saved in:
Published in: | SpringerPlus 2016-07, Vol.5 (1), p.1209, Article 1209 |
---|---|
Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Hibiscus tiliaceus
, locally known as Bhola was examined for phytochemical properties and its cytotoxic, antibacterial, analgesic and neuropharmacological activities using the ethanol extract of leaf and bark. The phytochemical analysis of the leaf extract indicated the presence of tannins, whereas bark extract indicated the presence of alkaloid, reducing sugar and tannins. A preliminary cytotoxicity of these extracts was determined by a simple and low cost assay using brine shrimp lethality. The leaf extract of the plant exhibited moderate cytotoxic effect (LC
50
: 20 µg/ml, LC
90
: 40 µg/ml) whereas the bark extract exhibited low cytotoxic effect (LC
50
: 50 µg/ml). In the analgesic test, the leaf extract showed comparatively high analgesic action than bark extract. There was no activity found in the leaf extract against the test bacterial strains, however bark extract exhibited a very little inhibitory effect on
Staphylococcus aureus
and
Staphylococcus epidermidis
. In the neuropharmacological test, the leaf and bark extract produced a decrease in both the time of onset of sleeping and the total sleeping time. The present study showed evidence that both leaf and bark extract of
H. tiliaceus
contain medicinally important bioactive compounds, thereby used as traditional medicine. |
---|---|
ISSN: | 2193-1801 2193-1801 |
DOI: | 10.1186/s40064-016-2891-0 |