Acute lymphoblastic leukemia with e1a3 BCR/ABL fusion protein. A report of two cases

B Acute Lymphoblastic leukemia (B-ALL) with Philadelphia chromosome (Ph') is a neoplasm of lymphoblast committed to the B cell lineage. The clinical presentation of B-ALL Ph'+ is similar to B-ALL, but is more common in adults than in children. The e1a3 rare variant is produced by the fusio...

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Published in:Experimental hematology & oncology 2016-07, Vol.5 (1), p.21, Article 21
Main Authors: López-Andrade, Bernardo, Sartori, Francesca, Gutiérrez, Antonio, García, Lucia, Cunill, Vanesa, Durán, María Antonia, Sampol, Antonia, Bernués, Marta, Iglesias, Julio, Ramos, Rafael, Lladó, Josep, Sánchez, María, Amat, Juan Carlos, Martínez-Serra, Jordi
Format: Article
Language:English
Subjects:
Acute lymphocytic leukemia
Adults
Bone marrow
Care and treatment
Case Report
Chromosomes
Development and progression
Genetic aspects
Leukemia
Polymerase chain reaction
Proteins
Tumors
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Summary:B Acute Lymphoblastic leukemia (B-ALL) with Philadelphia chromosome (Ph') is a neoplasm of lymphoblast committed to the B cell lineage. The clinical presentation of B-ALL Ph'+ is similar to B-ALL, but is more common in adults than in children. The e1a3 rare variant is produced by the fusion of BCR exon 1 to ABL exon 3. The presence of this translocation has been associated with good disease outcome for chronic myeloid leukemia in a very small series of only 5 cases; there is no such evidence for B-ALL. We report two new cases of B-ALL Ph+ with the rare e1a3 fusion transcript. The e1a3 and e1a2 (p190) transcripts have been reported to have a similar molecular weight and probably a similar clinical profile, thus in these cases the presence of e1a3 was associated with extramedullary infiltration and disease acceleration.
ISSN:2162-3619
2162-3619
DOI:10.1186/s40164-016-0049-y