Vaccine-preventable infections in Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE) is characterized by abnormal autoantibody production and clearance. Infections are among the most important causes of morbidity and mortality in SLE patients; they have an increased frequency of severe bacterial and viral infections possibly due to inherited geneti...

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Bibliographic Details
Published in:Human vaccines & immunotherapeutics 2016-03, Vol.12 (3), p.632-643
Main Authors: Murdaca, Giuseppe, Orsi, Andrea, Spanò, Francesca, Faccio, Valeria, Puppo, Francesco, Durando, Paolo, Icardi, Giancarlo, Ansaldi, Filippo
Format: Article
Language:English
Subjects:
Bacterial Infections - epidemiology
Bacterial Infections - prevention & control
erythematosus
Humans
infections
Lupus Erythematosus, Systemic - complications
Reviews
systemic lupus
vaccine-preventable
vaccines
Vaccines - administration & dosage
Vaccines - immunology
Virus Diseases - epidemiology
Virus Diseases - prevention & control
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Summary:Systemic Lupus Erythematosus (SLE) is characterized by abnormal autoantibody production and clearance. Infections are among the most important causes of morbidity and mortality in SLE patients; they have an increased frequency of severe bacterial and viral infections possibly due to inherited genetic and immunologic defects and to immunosuppressive therapies. In addition, infectious agents can switch on lupus disease expression and activity. Among the strategies to reduce the risk of infection, vaccination can be considered the most reliable option. Most vaccines are effective and safe in SLE patients, although in certain cases immunogenicity may be sub-optimal and vaccination can trigger a flare. Although these issues are currently unresolved, the risk benefit balance is in favor for vaccination to reduce the risk of infection in SLE patients. In the present review we discuss the preventive strategies currently recommended to reduce bacterial and viral infections in SLE.
ISSN:2164-5515
2164-554X
DOI:10.1080/21645515.2015.1107685