Associations of LBX1 gene and adolescent idiopathic scoliosis susceptibility: a meta-analysis based on 34,626 subjects

The results of studies investigating the association between the ladybird homeobox 1 (LBX1) gene polymorphisms and the risk of adolescent idiopathic scoliosis (AIS) are not all the same. As such, we performed a meta-analysis to estimate the association between LBX1 gene polymorphisms and AIS suscept...

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Bibliographic Details
Published in:BMC musculoskeletal disorders 2016-07, Vol.17 (1), p.309-309, Article 309
Main Authors: Cao, Yaqin, Min, Jikang, Zhang, Qianghua, Li, Heng, Li, Haidong
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Alleles
Asian Continental Ancestry Group - genetics
Child
Disease susceptibility
European Continental Ancestry Group - genetics
Female
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Genotype
Health aspects
Homeobox genes
Homeodomain Proteins - genetics
Homeotic genes
Humans
Male
Odds Ratio
Polymorphism, Single Nucleotide
Risk Factors
Scoliosis
Scoliosis - genetics
Sex Factors
Transcription Factors - genetics
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Summary:The results of studies investigating the association between the ladybird homeobox 1 (LBX1) gene polymorphisms and the risk of adolescent idiopathic scoliosis (AIS) are not all the same. As such, we performed a meta-analysis to estimate the association between LBX1 gene polymorphisms and AIS susceptibility. Relevant studies published before 15 November 2015 were identified by searching PubMed, EMBASE, ISI web of knowledge, EBSCO, CNKI and CBM. The strength of relationship was assessed by using odds ratios (ORs) and 95 % confidence interval (CI). A total number of eight case-control studies including 10,088 cases and 24,538 controls were identified. The results showed that T allele of rs111090870 increased AIS susceptibility in Asians (T vs. C, OR = 1.22, 95 % CI: 1.16-1.29, P 
ISSN:1471-2474
1471-2474
DOI:10.1186/s12891-016-1139-z