Obesity, metabolic health, and mortality in adults: a nationwide population-based study in Korea

BMI, metabolic health status, and their interactions should be considered for estimating mortality risk; however, the data are controversial and unknown in Asians. We aimed to investigate this issue in Korean population. Total 323175 adults were followed-up for 96 (60-120) (median [5-95%]) months in...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2016-07, Vol.6 (1), p.30329-30329, Article 30329
Main Authors: Yang, Hae Kyung, Han, Kyungdo, Kwon, Hyuk-Sang, Park, Yong-Moon, Cho, Jae-Hyoung, Yoon, Kun-Ho, Kang, Moo-Il, Cha, Bong-Yun, Lee, Seung-Hwan
Format: Article
Language:English
Subjects:
Adult
Aged
Body Mass Index
Databases, Factual
Diabetes Mellitus - mortality
Diabetes Mellitus - physiopathology
Dyslipidemias - mortality
Dyslipidemias - physiopathology
Female
Follow-Up Studies
Humans
Hypertension - mortality
Hypertension - physiopathology
Male
Metabolic Diseases - mortality
Metabolic Diseases - physiopathology
Middle Aged
Obesity - mortality
Obesity - physiopathology
Phenotype
Republic of Korea
Risk Factors
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BMI, metabolic health status, and their interactions should be considered for estimating mortality risk; however, the data are controversial and unknown in Asians. We aimed to investigate this issue in Korean population. Total 323175 adults were followed-up for 96 (60-120) (median [5-95%]) months in a nationwide population-based cohort study. Participants were classified as "obese" (O) or "non-obese" (NO) using a BMI cut-off of 25 kg/m(2). People who developed ≥1 metabolic disease component (hypertension, diabetes, dyslipidaemia) in the index year were considered "metabolically unhealthy" (MU), while those with none were considered "metabolically healthy" (MH). The MUNO group had a significantly higher risk of all-cause (hazard ratio, 1.28 [95% CI, 1.21-1.35]) and cardiovascular (1.88 [1.63-2.16]) mortality, whereas the MHO group had a lower mortality risk (all-cause: 0.81 [0.74-0.88]), cardiovascular: 0.73 [0.57-0.95]), compared to the MHNO group. A similar pattern was noted for cancer and other-cause mortality. Metabolically unhealthy status was associated with higher risk of all-cause and cardiovascular mortality regardless of BMI levels, and there was a dose-response relationship between the number of incident metabolic diseases and mortality risk. In conclusion, poor metabolic health status contributed more to mortality than high BMI did, in Korean adults.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep30329