High prevalence of luminal B breast cancer intrinsic subtype in Colombian women

Breast cancer is the most frequent malignancy in women worldwide. Distinct intrinsic subtypes of breast cancer have different prognoses, and their relative prevalence varies significantly among ethnic groups. Little is known about the prevalence of breast cancer intrinsic subtypes and their associat...

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Bibliographic Details
Published in:Carcinogenesis (New York) 2016-07, Vol.37 (7), p.669-676
Main Authors: Serrano-Gomez, Silvia Juliana, Sanabria-Salas, Maria Carolina, Hernández-Suarez, Gustavo, García, Oscar, Silva, Camilo, Romero, Alejandro, Mejía, Juan Carlos, Miele, Lucio, Fejerman, Laura, Zabaleta, Jovanny
Format: Article
Language:English
Subjects:
Adult
African Continental Ancestry Group - genetics
Aged
Biomarkers, Tumor - genetics
Breast Neoplasms - classification
Breast Neoplasms - epidemiology
Breast Neoplasms - genetics
Colombia - epidemiology
Female
Humans
Middle Aged
Neoplasm Recurrence, Local - classification
Neoplasm Recurrence, Local - epidemiology
Neoplasm Recurrence, Local - genetics
Original Manuscript
Prognosis
Receptor, ErbB-2 - genetics
Receptors, Estrogen - genetics
Receptors, Progesterone - genetics
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Summary:Breast cancer is the most frequent malignancy in women worldwide. Distinct intrinsic subtypes of breast cancer have different prognoses, and their relative prevalence varies significantly among ethnic groups. Little is known about the prevalence of breast cancer intrinsic subtypes and their association with clinicopathological data and genetic ancestry in Latin Americans. Immunohistochemistry surrogates from the 2013 St. Gallen International Expert Consensus were used to classify breast cancers in 301 patients from Colombia into intrinsic subtypes. We analyzed the distribution of subtypes by clinicopathological variables. Genetic ancestry was estimated from a panel of 80 ancestry informative markers. Luminal B breast cancer subtype was the most prevalent in our population (37.2%) followed by luminal A (26.3%), non-basal triple negative (NBTN) (11.6%), basal like (9%), human epidermal growth factor receptor 2 (HER2) enriched (8.6%) and unknown (7.3%). We found statistical significant differences in distribution between Colombian region (P = 0.007), age at diagnosis (P = 0.0139), grade (P < 0.001) and recurrence (P < 0.001) according to intrinsic subtype. Patients diagnosed with HER2-enriched, basal-like and NBTN breast cancer had the highest African ancestry. Future studies analyzing the molecular profiles of breast cancer in Colombian women will help us understand the molecular basis of this subtype distribution and compare the molecular characteristics of the different intrinsic subtypes in Colombian patients.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/bgw043