Acute exercise increases fibroblast growth factor 21 in metabolic organs and circulation

Fibroblast growth factor 21, a metabolic regulator, plays roles in lipolysis and glucose uptake in adipose tissues and skeletal muscles. Its expression in skeletal muscle is upregulated upon activation of the phosphatidylinositol 3‐kinase/Akt signaling pathway, which is induced by exercise and muscl...

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Bibliographic Details
Published in:Physiological reports 2016-06, Vol.4 (12), p.np-n/a
Main Authors: Tanimura, Yuko, Aoi, Wataru, Takanami, Yoshikazu, Kawai, Yukari, Mizushima, Katsura, Naito, Yuji, Yoshikawa, Toshikazu
Format: Article
Language:English
Subjects:
Adipose tissue
Adult
AKT protein
Animals
Circulation
Embryos
Endurance and Performance
Fibroblast growth factor 21
Fibroblast growth factors
Fibroblast Growth Factors - blood
Fibroblast Growth Factors - metabolism
Fibroblasts
glucose uptake
Growth factors
Humans
Lipolysis
Liver
Liver - metabolism
Male
Metabolism
Mice
Mice, Inbred ICR
Muscle contraction
Muscle, Skeletal - metabolism
Muscle, Skeletal - physiology
Musculoskeletal system
Original Research
Phosphorylation
phosphorylation of Akt
Physical Conditioning, Animal
Physical Conditioning, Human
Physiology
Signal transduction
Signalling Pathways
Skeletal Muscle
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Summary:Fibroblast growth factor 21, a metabolic regulator, plays roles in lipolysis and glucose uptake in adipose tissues and skeletal muscles. Its expression in skeletal muscle is upregulated upon activation of the phosphatidylinositol 3‐kinase/Akt signaling pathway, which is induced by exercise and muscle contraction. We examined the increase of fibroblast growth factor 21 after acute exercise in metabolic organs, especially skeletal muscles and circulation. Participants exercised on bicycle ergometers for 60 min at 75% of their V˙O2max. Venous blood samples were taken before exercise and immediately after exercise. In an animal study, male ICR mice were divided into sedentary and exercise groups. Mice in the exercise group performed treadmill exercises at 30 m min−1 for 60 min. Shortly thereafter, blood, liver, and skeletal muscle samples were taken from mice. Acute exercise induced the increase of serum fibroblast growth factor 21 in both humans and mice, and increased fibroblast growth factor 21 expression in the skeletal muscles and the liver of mice. Acute exercise activated Akt in mice skeletal muscle. Acute exercise increases fibroblast growth factor 21 concentrations in both serum and metabolic organs. Moreover, results show that acute exercise increased the expression of fibroblast growth factor 21 in skeletal muscle, accompanied by the phosphorylation of Akt in mice. We examined the increase of fibroblast growth factor 21 after acute exercise in metabolic organs, especially skeletal muscles, and circulation. In conclusion, acute exercise increases fibroblast growth factor 21 concentrations in both serum and metabolic organs. Moreover, results show that acute exercise increased the expression of Fibroblast growth factor 21 in skeletal muscle, accompanied by the phosphorylation of Akt in mice.
ISSN:2051-817X
2051-817X
DOI:10.14814/phy2.12828