Identification of cutoff points for Homeostatic Model Assessment for Insulin Resistance index in adolescents: systematic review

To identify cutoff points of the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index established for adolescents and discuss their applicability for the diagnosis of insulin resistance in Brazilian adolescents. A systematic review was performed in the PubMed, Lilacs and SciELO databa...

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Published in:Revista Paulista de Pediatria 2016-06, Vol.34 (2), p.234-242
Main Authors: Andrade, Maria Izabel Siqueira de, Oliveira, Juliana Souza, Leal, Vanessa Sá, Lima, Niedja Maria Silva da, Costa, Emília Chagas, Aquino, Nathalia Barbosa de, Lira, Pedro Israel Cabral de
Format: Article
Language:English
Subjects:
Adolescent
Adolescente
Curva ROC
Insulin resistance
Resistência à insulina
Review
Revisão
ROC curve
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Summary:To identify cutoff points of the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index established for adolescents and discuss their applicability for the diagnosis of insulin resistance in Brazilian adolescents. A systematic review was performed in the PubMed, Lilacs and SciELO databases, using the following descriptors: “adolescents”, “insulin resistance” and “Receiver Operating Characteristics Curve”. Original articles carried out with adolescents published between 2005 and 2015 in Portuguese, English or Spanish languages, which included the statistical analysis using Receiver Operating Characteristics Curve to determine the index cutoff (HOMA-IR) were included. A total of 184 articles were identified and after the study phases were applied, seven articles were selected for the review. All selected studies established their cutoffs using a Receiver Operating Characteristics Curve, with the lowest observed cutoff of 1.65 for girls and 1.95 for boys and the highest of 3.82 for girls and 5.22 for boys. Of the studies analyzed, one proposed external validity, recommending the use of the HOMA-IR cutoff>2.5 for both genders. The HOMA-IR index constitutes a reliable method for the detection of insulin resistance in adolescents, as long as it uses cutoffs that are more adequate for the reality of the study population, allowing early diagnosis of insulin resistance and enabling multidisciplinary interventions aiming at health promotion of this population. Identificar os pontos de corte do índice Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) estabelecidos para adolescentes e discutir a sua aplicabilidade para o diagnóstico da resistência à insulina em adolescentes brasileiros. Revisão sistemática feita nas bases de dados PubMed, Lilacs e SciELO com os descritores “Adolescentes”, “Resistência à insulina” e “Curva ROC”. Foram incluídos artigos originais, publicados entre 2005 e 2015, conduzidos com adolescentes, no idioma português, inglês ou espanhol e incluindo análise estatística com uso da curva ROC para determinação dos pontos de corte do índice (HOMA-IR). Foram identificados 184 artigos e, após a aplicação das etapas do procedimento, foram selecionados sete para compor a revisão. Todos os estudos selecionados estabeleceram seus pontos de corte com a curva ROC. O menor ponto de corte observado foi de 1,65 para meninas e 1,95 para meninos e o maior de 3,82 para meninas e 5,22 para meninos. Dos estudos analisados, um propôs validade
ISSN:2359-3482
0103-0582
1984-0462
2359-3482
1984-0462
DOI:10.1016/j.rppede.2016.01.004