Evaluation of anticardiolipin antibodies in tobacco users and non-tobacco users with severe chronic periodontal disease

Aims: Many studies have proven that b2-glycoprotein-I-dependent anticardiolipin is elevated in periodontal diseases. Systemic lupus erythematosus and antiphospholipid syndrome, which are usually associated with high antiphospholipid antibodies, are more prone to adverse pregnancy outcomes and cardio...

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Published in:Journal of International Society of Preventive and Community Dentistry 2016-05, Vol.6 (3), p.256-260
Main Authors: Yadalam, Pradeep, Pandian, Raja, Ravishankar, P, Vartharajan, Kalaivani, Subramaniam, Srinath, Dinakar, Mithra
Format: Article
Language:English
Subjects:
Cardiovascular disease
Confidence intervals
Consent
Glycoproteins
Heart attacks
Immunoglobulins
Lupus
Mortality
Original
Peptides
Sample size
Smoking
Studies
Tobacco
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Summary:Aims: Many studies have proven that b2-glycoprotein-I-dependent anticardiolipin is elevated in periodontal diseases. Systemic lupus erythematosus and antiphospholipid syndrome, which are usually associated with high antiphospholipid antibodies, are more prone to adverse pregnancy outcomes and cardiovascular sequelae. Therefore, the aim of the present study is to evaluate IgG, IgM anticardiolipin antibodies in tobacco users and non-tobacco users with severe chronic periodontal disease. Materials and Methods: Based on the Armitage classification, 2000, 40 severe periodontitis (group D) (mean clinical attachment loss greater than 2.5 mm) male patients were selected for the study with the age range of 35-65 years and good general health from the Department of periodontics, SRM Kattankulathur Dental College, Chennai. They were classified as smokers (20 subjects) and non-smokers (20 subjects). Blood samples were collected and IgG, IgM antibodies were semi-quantitatively analyzed by enzyme-linked immunosorbent assay. The data thus collected were statistically analyzed by independent student's t-test. Results: Results showed that smokers with severe periodontitis exhibited marked increase in anticardiolipin IgG, IgM compared to non-smokers. They showed a positive correlation and statistical significance (P < 0.0001) between mean clinical attachment loss and IgG and IgM values. Conclusions: Results showed a rise in anticardiolipin antibodies in smokers with severe periodontitis, which indicates that these patients are more prone to coronary heart disease.
ISSN:2231-0762
2250-1002
DOI:10.4103/2231-0762.183115