Procalcitonin as diagnostic marker of infection in solid tumors patients with fever

In oncologic patients fever is a non-specific clinical marker of different clinical settings. Procalcitonin (PCT) seems to be the most promising infection marker. We aimed to define the potential role of PCT as an earlier diagnostic marker in patients with fever and solid tumor. This retrospective s...

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Bibliographic Details
Published in:Scientific reports 2016-06, Vol.6 (1), p.28090-28090, Article 28090
Main Authors: Vincenzi, B, Fioroni, I, Pantano, F, Angeletti, S, Dicuonzo, G, Zoccoli, A, Santini, D, Tonini, G
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibiotics
Area Under Curve
Automation
Bacterial infections
Biomarkers - blood
Blood Culture
Calcitonin - blood
Cancer therapies
College campuses
Female
Fever - etiology
Gram-Negative Bacterial Infections - complications
Gram-Negative Bacterial Infections - diagnosis
Gram-Positive Bacterial Infections - complications
Gram-Positive Bacterial Infections - diagnosis
Humans
Infections
Laboratories
Lung cancer
Male
Middle Aged
Mycoses - complications
Mycoses - diagnosis
Neoplasms - complications
Neoplasms - pathology
Neutropenia
Observational studies
Oncology
Patients
Retrospective Studies
ROC Curve
Sensitivity and Specificity
Tumors
Urogenital system
Young Adult
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Summary:In oncologic patients fever is a non-specific clinical marker of different clinical settings. Procalcitonin (PCT) seems to be the most promising infection marker. We aimed to define the potential role of PCT as an earlier diagnostic marker in patients with fever and solid tumor. This retrospective study enrolled 431 patients. All of them performed hemoculture (HE) and basal PCT assessment (reference laboratory cut-off: ≤0.5 or >0.5 ng/dL) before starting antibiotic therapy. Gram positive (G+), negative (G-) or Fungi infection were detected. A statistically significant difference in PCT levels between patients with positive and negative HE was observed (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep28090