Statin intake is associated with MMP-1 level in gingival crevicular fluid of patients with periodontitis

Background This study was conducted to assess whether statin intake is associated with clinical parameters of periodontitis and matrix metalloproteinase (MMP) levels in gingival crevicular fluid (GCF) of non‐diabetic and diabetic patients. Methods We first determined the effect of simvastatin on MMP...

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Bibliographic Details
Published in:Oral diseases 2016-07, Vol.22 (5), p.438-444
Main Authors: Poston, CJ, Pierce, TC, Li, Y, Brinson, CW, Lu, Z, Lauer, AW, Leite, RS, Huang, Y
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Glucose - metabolism
Collagenases - genetics
Collagenases - metabolism
Dentistry
Diabetes
Diabetes Complications - drug therapy
Diabetes Complications - metabolism
diabetes mellitus
Diabetes Mellitus - drug therapy
Female
Gingival Crevicular Fluid - drug effects
Gingival Crevicular Fluid - metabolism
Gum disease
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics
Lipopolysaccharides - pharmacology
Male
Matrix Metalloproteinase 1 - genetics
Matrix Metalloproteinase 1 - metabolism
Matrix Metalloproteinase 8 - genetics
Matrix Metalloproteinase 8 - metabolism
Matrix Metalloproteinase 9 - genetics
Matrix Metalloproteinase 9 - metabolism
matrix metalloproteinase-1
Middle Aged
Periodontal Attachment Loss
periodontitis
Periodontitis - genetics
Periodontitis - metabolism
Simvastatin - pharmacology
statin
Statins
Up-Regulation
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Summary:Background This study was conducted to assess whether statin intake is associated with clinical parameters of periodontitis and matrix metalloproteinase (MMP) levels in gingival crevicular fluid (GCF) of non‐diabetic and diabetic patients. Methods We first determined the effect of simvastatin on MMP expression in mononuclear cells. We then recruited 117 non‐diabetic and diabetic patients, who all had periodontitis and took or did not take statin, and measured periodontal probing depth (PPD) and clinical attachment level (CAL), and collected gingival crevicular fluid (GCF) to quantify MMPs. Results The in vitro studies showed that simvastatin potently inhibited the expression of MMP‐1, MMP‐8, and MMP‐9 upregulated by lipopolysaccharide (LPS) and high glucose in mononuclear cells. The patient study showed that, after adjusting for age and smoking status, PPD in diabetic patients on statin was significantly less than that in diabetic patients not on statin. MMP‐1 level in GCF of non‐diabetic and diabetic patients on statin was lower than that of non‐diabetic and diabetic patients not on statin, respectively. No difference was found for MMP‐8 and ‐9 levels in GCF. Conclusion Statin intake is associated with reduced PPD in diabetic patients and MMP‐1 level in GCF in either non‐diabetic or diabetic patients.
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.12474