Serum Surfactant Protein D and Haptoglobin as Potential Biomarkers for Inflammatory Airway Disease in Horses

BACKGROUND: The identification of serum biomarkers of lung inflammation would facilitate the diagnosis of inflammatory airway disease (IAD) in horses. HYPOTHESIS: Horses with IAD have higher serum concentrations of markers of inflammation compared to controls. ANIMALS: Twelve horses with IAD and 10...

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Published in:Journal of veterinary internal medicine 2015-11, Vol.29 (6), p.1707-1711
Main Authors: Bullone, M., Lagarde, M., Vargas, A., Lavoie, J.‐P.
Format: Article
Language:English
Subjects:
Acute phase proteins
Animals
Biomarker
Biomarkers
Bronchoalveolar Lavage Fluid - chemistry
Case-Control Studies
EQUID
Female
Gene Expression Regulation
Haptoglobins - chemistry
Haptoglobins - metabolism
Horse Diseases - blood
Horse Diseases - diagnosis
Horses
Inflammation - blood
Inflammation - metabolism
Inflammation - veterinary
Lung
Male
Pulmonary Surfactant-Associated Protein D - blood
Pulmonary Surfactant-Associated Protein D - chemistry
Pulmonary Surfactant-Associated Protein D - metabolism
Respiratory Tract Diseases - blood
Respiratory Tract Diseases - metabolism
Respiratory Tract Diseases - veterinary
sTREM‐1
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Summary:BACKGROUND: The identification of serum biomarkers of lung inflammation would facilitate the diagnosis of inflammatory airway disease (IAD) in horses. HYPOTHESIS: Horses with IAD have higher serum concentrations of markers of inflammation compared to controls. ANIMALS: Twelve horses with IAD and 10 control horses. METHODS: This was a prospective case–control study. Blood and BALF were collected from horses with IAD and controls. Serum concentration of surfactant protein D (SP‐D), haptoglobin, serum amyloid A (SAA) and of the soluble form of triggering receptor expressed on myeloid cells 1 (sTREM‐1) was measured using commercial ELISA tests. RESULTS: Horses with IAD had higher serum concentration (log‐transformed values) of SP‐D (mean ± SD: 1.773 ± 0.51), haptoglobin (6.657 ± 0.202) and SAA (0.128 ± 0.396) compared to controls (0.942 ± 0.226, 6.38 ± 0.22, −0.398 ± 0.319, respectively; P 
ISSN:0891-6640
1939-1676
DOI:10.1111/jvim.13602