Reduced Diagnostic Performance of Two Norovirus Antigen Enzyme Immunoassays for the Emergent Genogroup II Genotype 17 Kawasaki 2014 Variant

Two commonly used norovirus enzyme immunoassays have reduced diagnostic performance, with clinical sensitivities ranging from 11% to 35% for the detection of the recently emerging genogroup II genotype 17 (GII.17) Kawasaki 2014 variant that caused the majority of infections in Asia during the winter...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical microbiology 2016-06, Vol.54 (6), p.1650-1652
Main Authors: Chan, Martin C W, Kwok, Kirsty, Hung, Tin-Nok, Chan, Paul K S
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antigens, Viral - analysis
Asia
Caliciviridae Infections - diagnosis
Child
Child, Preschool
Clinical Laboratory Techniques - methods
False Negative Reactions
Female
Genotype
Humans
Immunoenzyme Techniques - methods
Male
Middle Aged
Norovirus
Norovirus - classification
Norovirus - genetics
Norovirus - isolation & purification
Sensitivity and Specificity
Virology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two commonly used norovirus enzyme immunoassays have reduced diagnostic performance, with clinical sensitivities ranging from 11% to 35% for the detection of the recently emerging genogroup II genotype 17 (GII.17) Kawasaki 2014 variant that caused the majority of infections in Asia during the winter of 2014 to 2015. False-negative results can compromise infection control and patient management.
ISSN:0095-1137
1098-660X
DOI:10.1128/jcm.00350-16