Squamous Cell Cancers: A Unified Perspective on Biology and Genetics

Squamous cell carcinomas (SCCs) represent the most frequent human solid tumors and are a major cause of cancer mortality. These highly heterogeneous tumors arise from closely interconnected epithelial cell populations with intrinsic self-renewal potential inversely related to the stratified differen...

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Bibliographic Details
Published in:Cancer cell 2016-05, Vol.29 (5), p.622-637
Main Authors: Dotto, G. Paolo, Rustgi, Anil K.
Format: Article
Language:English
Subjects:
Alcohol Drinking - adverse effects
Carcinoma, Squamous Cell - etiology
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - therapy
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease - genetics
Humans
Infection - complications
Models, Genetic
Mutation
Smoking - adverse effects
Ultraviolet Rays - adverse effects
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Summary:Squamous cell carcinomas (SCCs) represent the most frequent human solid tumors and are a major cause of cancer mortality. These highly heterogeneous tumors arise from closely interconnected epithelial cell populations with intrinsic self-renewal potential inversely related to the stratified differentiation program. SCCs can also originate from simple or pseudo-stratified epithelia through activation of quiescent cells and/or a switch in cell-fate determination. Here, we focus on specific determinants implicated in the development of SCCs by recent large-scale genomic, genetic, and epigenetic studies, and complementary functional analysis. The evidence indicates that SCCs from various body sites, while clinically treated as separate entities, have common determinants, pointing to a unified perspective of the disease and potential new avenues for prevention and treatment. Dotto and Rustgi focus on specific determinants implicated in the development of squamous cell carcinomas (SCCs) by recent large-scale genomic, genetic, and epigenetic studies, and complementary functional analysis. Their evidence indicates that SCCs from various body sites, while clinically treated as separate entities, have common determinants, pointing to a unified perspective of the disease and potential new avenues for prevention and treatment.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccell.2016.04.004