Management of bipolar disorder in the intercontinental region: an international, multicenter, non-interventional, cross-sectional study in real-life conditions

Most of the existing data on real-life management of bipolar disorder are from studies conducted in western countries (mostly United States and Europe). This multinational, observational cohort study aimed to describe the management and clinical outcomes of bipolar patients in real-life conditions a...

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Bibliographic Details
Published in:Scientific reports 2016-05, Vol.6 (1), p.25920-25920, Article 25920
Main Authors: Samalin, Ludovic, Vieta, Eduard, Okasha, Tarek Ahmed, Uddin, Mm Jalal, Ahmadi Abhari, Seyed Ali, Nacef, Fethi, Mishyiev, Vyacheslav, Aizenberg, Dovi, Ratner, Yaël, Melas-Melt, Lydie, Sedeki, Idir, Llorca, Pierre Michel
Format: Article
Language:English
Subjects:
Clinical neuropsychology
Cognitive science
Cognitive Sciences
Life Sciences
Manic-depressive illness
Neurobiology
Neurons and Cognition
Neuropsicologia clínica
Neuroscience
Psychology and behavior
Trastorn bipolar
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Summary:Most of the existing data on real-life management of bipolar disorder are from studies conducted in western countries (mostly United States and Europe). This multinational, observational cohort study aimed to describe the management and clinical outcomes of bipolar patients in real-life conditions across various intercontinental countries (Bangladesh, Egypt, Iran, Israel, Tunisia, and Ukraine). Data on socio-demographic and disease characteristics, current symptomatology, and pharmacological treatment were collected. Comparisons between groups were performed using standard statistical tests. Overall, 1180 patients were included. The median time from initial diagnosis was 80 months. Major depressive disorder was the most common initial diagnosis. Mood stabilizers and antipsychotics were the most common drugs being prescribed at the time of the study. Antidepressants (mainly selective serotonin uptake inhibitors [SSRIs]) were administered to 36.1% of patients. Patients with bipolar I disorder received higher number of antipsychotics and anxiolytics than those with bipolar II disorder (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep25920