Association of TLR and TREM-1 gene polymorphisms with atherosclerosis severity in a Russian population

Local vascular immune response is primarily initiated via Toll-like receptors (TLRs) and triggering receptor expressed on myeloid cells-1 (TREM-1). We previously showed that certain TLR and TREM-1 gene polymorphisms are associated with coronary artery disease (CAD). Therefore, we hypothesized that t...

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Bibliographic Details
Published in:Meta Gene 2016-09, Vol.9, p.76-89
Main Authors: Kutikhin, Anton G., Ponasenko, Anastasia V., Khutornaya, Maria V., Yuzhalin, Arseniy E., Zhidkova, Irina I., Salakhov, Ramil R., Golovkin, Alexey S., Barbarash, Olga L., Barbarash, Leonid S.
Format: Article
Language:English
Subjects:
Atherosclerosis
Coronary artery disease
Gene polymorphisms
Research Paper
Toll-like receptors
Triggering receptor expressed on myeloid cells-1
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Summary:Local vascular immune response is primarily initiated via Toll-like receptors (TLRs) and triggering receptor expressed on myeloid cells-1 (TREM-1). We previously showed that certain TLR and TREM-1 gene polymorphisms are associated with coronary artery disease (CAD). Therefore, we hypothesized that these gene polymorphisms are associated with atherosclerosis severity. This study included 292 consecutive patients with CAD who were admitted to the Research Institute for Complex Issues of Cardiovascular Diseases (Kemerovo, Russian Federation) during 2011–2012. Sample genotyping was performed in 96-well format using the TaqMan SNP genotyping assay. We found that C/C genotype of the rs3804099 polymorphism within TLR2 gene and T/T genotype of the rs4711668 polymorphism within TREM-1 gene were significantly associated with severe coronary atherosclerosis while C allele of the rs5743551 polymorphism within TLR1 gene, A/G genotype of the rs4986790 polymorphism and C/T genotype of the rs4986791 polymorphism within TLR4 gene, and C allele of the rs3775073 polymorphism within TLR6 gene were significantly associated with severe noncoronary atherosclerosis. However, A/A genotype of the rs5743810 polymorphism within TLR6 gene was significantly associated with mild noncoronary atherosclerosis. We conclude that certain TLR and TREM-1 gene polymorphisms are significantly associated with atherosclerosis severity in a Russian population. •Rs3804099 polymorphism of TLR2 gene is associated with severe coronary atherosclerosis.•Rs4711668 polymorphism of TREM-1 gene is associated with severe coronary atherosclerosis.•Rs5743551 polymorphism of TLR1 gene is associated with severe noncoronary atherosclerosis.•Rs4986790 and rs4986791 polymorphisms of TLR4 gene are associated with severe noncoronary atherosclerosis.•Rs3775073 polymorphism of TLR6 gene is associated with severe noncoronary atherosclerosis.
ISSN:2214-5400
2214-5400
DOI:10.1016/j.mgene.2016.04.001