Combined hepatocellular cholangiocarcinoma: Controversies to be addressed

Combined hepatocellular cholangiocarcinoma(CHC) accounts for 0.4%-14.2% of primary liver cancer cases and possesses pathological features of both hepatocellular carcinoma and cholangiocarcinoma. Since this disease was first described and classified in 1949, the classification of CHC has continuously...

Full description

Saved in:
Bibliographic Details
Published in:World journal of gastroenterology : WJG 2016-05, Vol.22 (18), p.4459-4465
Main Authors: Wang, An-Qiang, Zheng, Yong-Chang, Du, Juan, Zhu, Cheng-Pei, Huang, Han-Chun, Wang, Shan-Shan, Wu, Liang-Cai, Wan, Xue-Shuai, Zhang, Hao-Hai, Miao, Ruo-Yu, Sang, Xin-Ting, Zhao, Hai-Tao
Format: Article
Language:English
Subjects:
Bile Duct Neoplasms - classification
Bile Duct Neoplasms - genetics
Bile Duct Neoplasms - pathology
Bile Ducts, Intrahepatic - pathology
Carcinoma, Hepatocellular - classification
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - pathology
cell
Cell Differentiation
Cell Lineage
cholangiocarcinoma
Cholangiocarcinoma - classification
Cholangiocarcinoma - genetics
Cholangiocarcinoma - pathology
classification
Combined
Genetic Predisposition to Disease
hepatocellular
Humans
Liver Neoplasms - classification
Liver Neoplasms - genetics
Liver Neoplasms - pathology
Minireviews
Neoplasms, Complex and Mixed
origin
Pathology
Phenotype
Progenitor
Prognosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Combined hepatocellular cholangiocarcinoma(CHC) accounts for 0.4%-14.2% of primary liver cancer cases and possesses pathological features of both hepatocellular carcinoma and cholangiocarcinoma. Since this disease was first described and classified in 1949, the classification of CHC has continuously evolved. The latest definition and classification of CHC by the World Health Organization is based on the speculation that CHC arises from hepatic progenitor cells. However, there is no evidence demonstrating the common origin of different components of CHC. Furthermore, the definition of CHC subtypes is still ambiguous and the identification of CHC subtype when a single tumor contains many components has remained unresolved. In addition, there is no summary on the newly recognized histopathology features or the contribution of CHC components to prognosis and outcome of this disease. Here we provide a review of the current literature to address these questions.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v22.i18.4459