Relationship between lung function and quantitative computed tomographic parameters of airway remodeling, air trapping, and emphysema in patients with asthma and chronic obstructive pulmonary disease: A single-center study

Background There is a paucity of studies comparing asthma and chronic obstructive pulmonary disease (COPD) based on thoracic quantitative computed tomographic (QCT) parameters. Objectives We sought to compare QCT parameters of airway remodeling, air trapping, and emphysema between asthmatic patients...

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Published in:Journal of allergy and clinical immunology 2016-05, Vol.137 (5), p.1413-1422.e12
Main Authors: Hartley, Ruth A., MBcHB, MRCS, Barker, Bethan L., MBBS, MRCP, Newby, Chris, PhD, Pakkal, Mini, FRCR, Baldi, Simonetta, MD, PhD, Kajekar, Radhika, PhD, Kay, Richard, PhD, Laurencin, Marie, PhD, Marshall, Richard P., PhD, MRCP, Sousa, Ana R., PhD, Parmar, Harsukh, PhD, Siddiqui, Salman, PhD, MRCP, Gupta, Sumit, PhD, FRCR, MRCP, Brightling, Chris E., PhD, FRCP
Format: Article
Language:English
Subjects:
Adult
Aged
Airway Remodeling
Allergy and Immunology
Asthma
Asthma - diagnostic imaging
Asthma - pathology
Asthma - physiopathology
Asthma and Lower Airway Disease
asthma-COPD overlap syndrome
Chronic illnesses
Chronic obstructive pulmonary disease
emphysema
Female
Forced Expiratory Volume
gas trapping
Health risk assessment
Humans
Male
Middle Aged
Patients
Pulmonary Disease, Chronic Obstructive - diagnostic imaging
Pulmonary Disease, Chronic Obstructive - pathology
Pulmonary Disease, Chronic Obstructive - physiopathology
Pulmonary Emphysema - diagnostic imaging
Pulmonary Emphysema - pathology
Pulmonary Emphysema - physiopathology
quantitative computed tomography
small airway disease
Tomography, X-Ray Computed
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Summary:Background There is a paucity of studies comparing asthma and chronic obstructive pulmonary disease (COPD) based on thoracic quantitative computed tomographic (QCT) parameters. Objectives We sought to compare QCT parameters of airway remodeling, air trapping, and emphysema between asthmatic patients and patients with COPD and explore their relationship with airflow limitation. Methods Asthmatic patients (n = 171), patients with COPD (n = 81), and healthy subjects (n = 49) recruited from a single center underwent QCT and clinical characterization. Results Proximal airway percentage wall area (%WA) was significantly increased in asthmatic patients (62.5% [SD, 2.2]) and patients with COPD (62.7% [SD, 2.3]) compared with that in healthy control subjects (60.3% [SD, 2.2], P  
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.02.001