Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis

BACKGROUND AND PURPOSE—The debate over the fact that experimental drugs proposed for the treatment of stroke fail in the translation to the clinical situation has attracted considerable attention in the literature. In this context, we present a retrospective pooled analysis of a large data set from...

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Published in:	Stroke (1970) 2016-05, Vol.47 (5), p.1312-1318
Main Authors:	Orset, Cyrille, Haelewyn, Benoit, Allan, Stuart M, Ansar, Saema, Campos, Francesco, Cho, Tae Hee, Durand, Anne, El Amki, Mohamad, Fatar, Marc, Garcia-Yébenes, Isaac, Gauberti, Maxime, Grudzenski, Saskia, Lizasoain, Ignacio, Lo, Eng, Macrez, Richard, Margaill, Isabelle, Maysami, Samaneh, Meairs, Stephen, Nighoghossian, Norbert, Orbe, Josune, Paramo, Jose Antonio, Parienti, Jean-Jacques, Rothwell, Nancy J, Rubio, Marina, Waeber, Christian, Young, Alan R, Touzé, Emmanuel, Vivien, Denis
Format:	Article
Language:	English
Subjects:	Animals Brain Ischemia - drug therapy Brain Ischemia - pathology Disease Models, Animal Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - pharmacology Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - pathology Male Mice Mice, Inbred C57BL Stroke - drug therapy Stroke - pathology Tissue Plasminogen Activator - administration & dosage Tissue Plasminogen Activator - pharmacology
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