Uric acid in metabolic syndrome: From an innocent bystander to a central player

Abstract Uric acid, once viewed as an inert metabolic end-product of purine metabolism, has been recently incriminated in a number of chronic disease states, including hypertension, metabolic syndrome, diabetes, non-alcoholic fatty liver disease, and chronic kidney disease. Several experimental and...

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Bibliographic Details
Published in:European journal of internal medicine 2016-04, Vol.29, p.3-8
Main Authors: Kanbay, Mehmet, Jensen, Thomas, Solak, Yalcin, Le, Myphuong, Roncal-Jimenez, Carlos, Rivard, Chris, Lanaspa, Miguel A, Nakagawa, Takahiko, Johnson, Richard J
Format: Article
Language:English
Subjects:
Cardiovascular disease
Diabetes mellitus
Diabetes Mellitus - blood
Humans
Hypertension
Hypertension - blood
Hyperuricemia - blood
Internal Medicine
Kidney disease
Metabolic syndrome
Metabolic Syndrome - blood
Non-alcoholic Fatty Liver Disease - blood
Renal Insufficiency, Chronic - blood
Risk Factors
Uric acid
Uric Acid - blood
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Summary:Abstract Uric acid, once viewed as an inert metabolic end-product of purine metabolism, has been recently incriminated in a number of chronic disease states, including hypertension, metabolic syndrome, diabetes, non-alcoholic fatty liver disease, and chronic kidney disease. Several experimental and clinical studies support a role for uric acid as a contributory causal factor in these conditions. Here we discuss some of the major mechanisms linking uric acid to metabolic and cardiovascular diseases. At this time the key to understanding the importance of uric acid in these diseases will be the conduct of large clinical trials in which the effect of lowering uric acid on hard clinical outcomes is assessed. Elevated uric acid may turn out to be one of the more important remediable risk factors for metabolic and cardiovascular diseases.
ISSN:0953-6205
1879-0828
DOI:10.1016/j.ejim.2015.11.026