Rate of establishing the gut microbiota in infancy has consequences for future health

The gut of the human neonate is colonized rapidly after birth from an early sparse and highly distinct microbiota to a more adult-like and convergent state, within 1 to 3 years. The progression of colonizing bacterial species is non-random. During the first months of life several shifts commonly occ...

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Bibliographic Details
Published in:Gut microbes 2015-01, Vol.6 (5), p.321-325
Main Authors: Dogra, Shaillay, Sakwinska, Olga, Soh, Shu-E, Ngom-Bru, Catherine, Brück, Wolfram M, Berger, Bernard, Brüssow, Harald, Karnani, Neerja, Lee, Yung Seng, Yap, Fabian, Chong, Yap-Seng, Godfrey, Keith M, Holbrook, Joanna D
Format: Article
Language:English
Subjects:
Addendum
adiposity
Caesarean section
defining/profiling gut microbiome
Gastrointestinal Microbiome
gestational age
gut microbiota
harnessing microbial strategies for treatment of human disease
Health
Humans
immaturity
infancy
Infant
Infant, Newborn
Intestines - microbiology
obesity
prematurity
Time Factors
vaginal delivery
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Summary:The gut of the human neonate is colonized rapidly after birth from an early sparse and highly distinct microbiota to a more adult-like and convergent state, within 1 to 3 years. The progression of colonizing bacterial species is non-random. During the first months of life several shifts commonly occur in the species prevalent in our guts. Although the sequential progression of these species is remarkably consistent across individuals and geographies, there is inter-individual variation in the rate of progression. Our study and others suggest that the rate is influenced by environmental factors, and influences our future health. In this article, we review our recent contribution to cataloging the developing infant gut microbiota alongside other important recent studies. We suggest testable hypotheses that arise from this synthesis.
ISSN:1949-0976
1949-0984
DOI:10.1080/19490976.2015.1078051