The coaction of tonic and phasic dopamine dynamics

Tonic neurochemical dopamine activity underlies many brain functions; however a consensus on this important concentration has not yet been reached. In this work, we introduce in vivo fast-scan controlled-adsorption voltammetry to report tonic dopamine concentrations (90 ± 9 nM) and the dopamine diff...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-02, Vol.51 (12), p.2235-2238
Main Authors: Atcherley, Christopher W, Wood, Kevin M, Parent, Kate L, Hashemi, Parastoo, Heien, Michael L
Format: Article
Language:English
Subjects:
3,4-Dihydroxyphenylacetic Acid - chemistry
3,4-Dihydroxyphenylacetic Acid - metabolism
Adsorption
Animals
Ascorbic Acid - chemistry
Ascorbic Acid - metabolism
Brain - metabolism
Dopamine - chemistry
Dopamine - metabolism
Electrochemical Techniques
Mice
Monoamine Oxidase - metabolism
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Summary:Tonic neurochemical dopamine activity underlies many brain functions; however a consensus on this important concentration has not yet been reached. In this work, we introduce in vivo fast-scan controlled-adsorption voltammetry to report tonic dopamine concentrations (90 ± 9 nM) and the dopamine diffusion coefficient (1.05 ± 0.09 × 10(-6) cm(2) s(-1)) in the mouse brain.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc06165a