Maintaining K + balance on the low-Na + , high-K + diet

A low-Na , high-K diet (LNaHK) is considered a healthier alternative to the "Western" high-Na diet. Because the mechanism for K secretion involves Na reabsorptive exchange for secreted K in the distal nephron, it is not understood how K is eliminated with such low Na intake. Animals on a L...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 2016-04, Vol.310 (7), p.F581-F595
Main Authors: Cornelius, Ryan J, Wang, Bangchen, Wang-France, Jun, Sansom, Steven C
Format: Article
Language:English
Subjects:
Animals
Cells
Diet
Humans
Plasma
Potassium
Potassium, Dietary - metabolism
Reviews
Sodium, Dietary - metabolism
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Summary:A low-Na , high-K diet (LNaHK) is considered a healthier alternative to the "Western" high-Na diet. Because the mechanism for K secretion involves Na reabsorptive exchange for secreted K in the distal nephron, it is not understood how K is eliminated with such low Na intake. Animals on a LNaHK diet produce an alkaline load, high urinary flows, and markedly elevated plasma ANG II and aldosterone levels to maintain their K balance. Recent studies have revealed a potential mechanism involving the actions of alkalosis, urinary flow, elevated ANG II, and aldosterone on two types of K channels, renal outer medullary K and large-conductance K channels, located in principal and intercalated cells. Here, we review these recent advances.
ISSN:1931-857X
1522-1466
DOI:10.1152/ajprenal.00330.2015