Associations and prognostic implications of Eastern Cooperative Oncology Group performance status and tumoral LINE-1 methylation status in stage III colon cancer patients

Low methylation status of LINE-1 in tumors is associated with poor survival in patients with colon cancer. Eastern Cooperative Oncology Group performance status (ECOG-PS) is a method to assess the functional status of a patient. We retrospectively evaluated the relationship between ECOG-PS and LINE-...

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Bibliographic Details
Published in:Clinical epigenetics 2016-04, Vol.8 (36), p.36-36, Article 36
Main Authors: Chen, Duo, Wen, Xianyu, Song, Young Seok, Rhee, Ye-Young, Lee, Tae Hun, Cho, Nam Yun, Han, Sae-Won, Kim, Tae-You, Kang, Gyeong Hoon
Format: Article
Language:English
Subjects:
Adjuvant treatment
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Body mass index
Cancer
Cancer patients
Care and treatment
Chemotherapy
Colon cancer
Colonic Neoplasms - drug therapy
Colonic Neoplasms - genetics
Colonic Neoplasms - pathology
Colorectal cancer
Deoxyribonucleic acid
DNA
DNA Methylation
Female
Fluorouracil - administration & dosage
Fluorouracil - therapeutic use
Genomes
Health aspects
Humans
Leucovorin - administration & dosage
Leucovorin - therapeutic use
Long Interspersed Nucleotide Elements
Lymphatic system
Male
Medical prognosis
Metastasis
Methylation
Microsatellite Instability
Middle Aged
Mortality
Neoplasm Recurrence, Local
Organoplatinum Compounds - administration & dosage
Organoplatinum Compounds - therapeutic use
Prognosis
Retrospective Studies
Sample size
Software
Standard deviation
Survival Analysis
Treatment Outcome
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Summary:Low methylation status of LINE-1 in tumors is associated with poor survival in patients with colon cancer. Eastern Cooperative Oncology Group performance status (ECOG-PS) is a method to assess the functional status of a patient. We retrospectively evaluated the relationship between ECOG-PS and LINE-1 methylation in colorectal cancers (CRCs) and their prognostic impact in CRC or colon cancer patients receiving adjuvant 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX). LINE-1 methylation and microsatellite instability were analyzed in stage III or high-risk stage II CRCs (n = 336). LINE-1 methylation levels were correlated with clinicopathological features, including PS and recurrence-free survival (RFS). The association between the tumoral LINE-1 methylation level and PS was observed (OR = 2.56, P 
ISSN:1868-7075
1868-7083
1868-7083
1868-7075
DOI:10.1186/s13148-016-0203-8