Effect of lifestyle intervention on the hormonal profile of frail, obese older men

OBJECTIVE: Obesity-associated hypogonadism is hypothesized to be due to the suppressive effect of high estradiol (from an increase in aromatase activity present in the abundant adipose tissue) on the hypothalamic-pituitary-gonadal unit resulting in low testosterone production. Although weight loss h...

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Bibliographic Details
Published in:The Journal of nutrition, health & aging health & aging, 2016-03, Vol.20 (3), p.334-340
Main Authors: Armamento-Villareal, R, Aguirre, L. E, Qualls, C, Villareal, Dennis T
Format: Article
Language:English
Subjects:
Activities of daily living
adipose tissue
Aged
Aging
aromatase
Body fat
diet
Diet, Reducing
elderly
enzyme-linked immunosorbent assay
estradiol
Estradiol - blood
exercise
Exercise - physiology
Fitness training programs
Frail Elderly
Frailty
Geriatrics/Gerontology
Health care
hospitals
Humans
Immunoassay
Intervention
Life Style
lifestyle
Lifestyles
Male
Medicine
Medicine & Public Health
men
Neurosciences
Nutrition
Obesity
Obesity - blood
patients
Primary Care Medicine
Quality of life
Quality of Life Research
radioimmunoassays
randomized clinical trials
sex hormone-binding globulin
Sex Hormone-Binding Globulin - analysis
Testosterone
Testosterone - blood
Weight control
Weight Loss
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Summary:OBJECTIVE: Obesity-associated hypogonadism is hypothesized to be due to the suppressive effect of high estradiol (from an increase in aromatase activity present in the abundant adipose tissue) on the hypothalamic-pituitary-gonadal unit resulting in low testosterone production. Although weight loss has been found to be effective in reducing estradiol and raising testosterone levels in studies of younger men, its effect in frail, obese older men is understudied. Thus, the objective of this study was to determine the effect of lifestyle intervention on hormone levels in frail, obese older men. DESIGN: Randomized controlled trial of lifestyle intervention in frail, obese older men (≥65 yo) for 1 year. SETTING: University hospital. METHODS: Forty frail, obese elderly men were randomized, for a 52-week study, to any of the following treatment groups: (1) control group, (2) diet-induced weight loss group (diet group), (3) exercise training group (exercise group), and (4) diet-induced weight loss and exercise training group (diet.exercise group). The objective was to achieve a ∼10 % weight loss at 6 months and maintain this weight for an additional 6 months. Physical function was assessed by the modified physical performance testing (modified PPT). Estradiol was measured by radioimmunoassay, testosterone by automated immunoassay, and sex hormone-binding globulin by enzyme-linked immunoassay. RESULTS: After 12 months of intervention, diet alone resulted in a weight loss of −10.1 ± 1.9 kg in the diet group and −9.1 ± 0.9 kg in the diet-exercise group. This resulted in a significant decrease (both p
ISSN:1279-7707
1760-4788
DOI:10.1007/s12603-016-0698-x