Naturally Occurring Major and Minor Capsid Protein Variants of Human Papillomavirus 45 (HPV45): Differential Recognition by Cross-Neutralizing Antibodies Generated by HPV Vaccines

We investigated naturally occurring variation within the major (L1) and minor (L2) capsid proteins of human papillomavirus genotype 45 (HPV45). Pseudoviruses (PsVs) representing HPV45 sublineages A1, A2, A3, B1, and B2 exhibited comparable particle-to-infectivity ratios and morphologies but demonstr...

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Bibliographic Details
Published in:Journal of virology 2015-12, Vol.90 (6), p.3247-3252
Main Authors: Godi, Anna, Facchetti, Alessandra, Bissett, Sara L, Cocuzza, Clementina, Miller, Elizabeth, Beddows, Simon
Format: Article
Language:English
Subjects:
Alphapapillomavirus - genetics
Alphapapillomavirus - immunology
Antibodies, Neutralizing - blood
Antibodies, Neutralizing - immunology
Antibodies, Viral - blood
Antibodies, Viral - immunology
Capsid Proteins - genetics
Capsid Proteins - immunology
Cross Reactions
Genetic Diversity and Evolution
Genetic Variation
Humans
Neutralization Tests
Papillomavirus Vaccines - administration & dosage
Papillomavirus Vaccines - immunology
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Summary:We investigated naturally occurring variation within the major (L1) and minor (L2) capsid proteins of human papillomavirus genotype 45 (HPV45). Pseudoviruses (PsVs) representing HPV45 sublineages A1, A2, A3, B1, and B2 exhibited comparable particle-to-infectivity ratios and morphologies but demonstrated both increased (A2, A3, and B1) and decreased (B2) sensitivities to cross-neutralization by HPV vaccine antibodies compared to that of the A1 sublineage. Mutant PsVs identified HI loop residue 357 as being critical for conferring this differential sensitivity.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.02859-15