Developmental ethanol exposure-induced sleep fragmentation predicts adult cognitive impairment

Highlights • Developmental ethanol exposure induces slow-wave sleep fragmentation in adults. • Early ethanol-induced sleep fragmentation correlates with cognitive impairment. • Early ethanol also impairs sleep plasticity following conditioning. • Life-long sleep disruption may be a critical factor i...

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Bibliographic Details
Published in:Neuroscience 2016-05, Vol.322, p.18-27
Main Authors: Wilson, D.A, Masiello, K, Lewin, M.P, Hui, M, Smiley, J.F, Saito, M
Format: Article
Language:English
Subjects:
Alcohol-Related Disorders - physiopathology
Animals
Body Temperature - physiology
Central Nervous System Depressants - toxicity
circadian rhythm
Circadian Rhythm - physiology
Cognitive Dysfunction - diagnosis
Cognitive Dysfunction - physiopathology
Conditioning (Psychology) - physiology
Disease Models, Animal
Ethanol - toxicity
Fear - physiology
fetal alcohol disorder
insomnia
Memory - physiology
Mice, Inbred C57BL
Motor Activity - physiology
Neurology
Prognosis
Sleep - physiology
Sleep Deprivation - physiopathology
sleep fragmentation
slow-wave sleep
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Summary:Highlights • Developmental ethanol exposure induces slow-wave sleep fragmentation in adults. • Early ethanol-induced sleep fragmentation correlates with cognitive impairment. • Early ethanol also impairs sleep plasticity following conditioning. • Life-long sleep disruption may be a critical factor in cognitive disability following early ethanol.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.02.020