Antimicrobial peptides and wound healing: biological and therapeutic considerations

Repair of tissue wounds is a fundamental process to re‐establish tissue integrity and regular function. Importantly, infection is a major factor that hinders wound healing. Multicellular organisms have evolved an arsenal of host‐defense molecules, including antimicrobial peptides (AMPs), aimed at co...

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Bibliographic Details
Published in:Experimental dermatology 2016-03, Vol.25 (3), p.167-173
Main Authors: Mangoni, Maria Luisa, McDermott, Alison M., Zasloff, Michael
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - immunology
antibiotic resistance
Antimicrobial Cationic Peptides - immunology
antimicrobial peptide
Bacterial Infections - immunology
Caenorhabditis elegans
Cathelicidins - immunology
Drosophila melanogaster
Epithelial Cells - cytology
frog skin
Humans
Immune System
Immunity, Innate
innate immunity
Mice
Microbiota
Skin - immunology
skin infections
wound healing
Wound Healing - immunology
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Summary:Repair of tissue wounds is a fundamental process to re‐establish tissue integrity and regular function. Importantly, infection is a major factor that hinders wound healing. Multicellular organisms have evolved an arsenal of host‐defense molecules, including antimicrobial peptides (AMPs), aimed at controlling microbial proliferation and at modulating the host's immune response to a variety of biological or physical insults. In this brief review, we provide the evidence for a role of AMPs as endogenous mediators of wound healing and their promising therapeutic potential for the treatment of non‐life‐threatening skin and other epithelial injuries.
ISSN:0906-6705
1600-0625
DOI:10.1111/exd.12929