Familial autoimmunity in the Childhood Arthritis and Rheumatology Research Alliance registry

Clinically distinct autoimmune phenotypes share genetic susceptibility factors. We investigated the prevalence of familial autoimmunity among subjects with juvenile idiopathic arthritis (JIA), childhood systemic lupus erythematosus (cSLE) and juvenile dermatomyositis (JDM) in the CARRA Registry, the...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric Rheumatology 2016-03, Vol.14 (1), p.14-14, Article 14
Main Authors: Prahalad, Sampath, McCracken, Courtney E, Ponder, Lori A, Angeles-Han, Sheila T, Rouster Stevens, Kelly A, Vogler, Larry B, Langefeld, Carl D, Thompson, Susan D
Format: Article
Language:English
Subjects:
Arthritis, Juvenile - epidemiology
Arthritis, Juvenile - immunology
Autoimmunity
Biomedical Research
Care and treatment
Child
Child, Preschool
Complications and side effects
Development and progression
Female
Humans
Male
Prevalence
Registries
Retrospective Studies
Rheumatology - statistics & numerical data
Systemic lupus erythematosus
United States - epidemiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Clinically distinct autoimmune phenotypes share genetic susceptibility factors. We investigated the prevalence of familial autoimmunity among subjects with juvenile idiopathic arthritis (JIA), childhood systemic lupus erythematosus (cSLE) and juvenile dermatomyositis (JDM) in the CARRA Registry, the largest multicenter observational Registry for pediatric rheumatic disease. Children with JIA, cSLE and JDM enrolled in the CARRA Registry between May 2010 and May 2012 were investigated for differences in proportion of subjects who had first-degree relatives (FDR) with autoimmunity. If a significant difference was detected, pairwise comparisons, adjusted for multiple comparisons, were made. There were 4677 JIA, 639 cSLE and 440 JDM subjects. The proportion of subjects having FDR with any autoimmune disease in the JDM group (20.5 %) was less compared to subjects with JIA (31.8 %, p 
ISSN:1546-0096
1546-0096
DOI:10.1186/s12969-016-0075-7