FNDC5 is produced in the stomach and associated to body composition

The fibronectin type III domain-containing protein 5 (FNDC5) discovered in 2002 has recently gained attention due to its potential role in protecting against obesity. In rat, no data exist regarding FNDC5 production and regulation in the stomach. The aim of the present work was to determine the expr...

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Bibliographic Details
Published in:Scientific reports 2016-03, Vol.6 (1), p.23067-23067, Article 23067
Main Authors: Barja-Fernández, S, Folgueira, C, Castelao, C, Al-Massadi, O, Bravo, S B, Garcia-Caballero, T, Leis, R, Pardo, M, Casanueva, F F, Seoane, L M
Format: Article
Language:English
Subjects:
Adipose Tissue - growth & development
Adipose Tissue - metabolism
Animals
Antibodies
Body composition
Body Composition - genetics
Body fat
Energy balance
Energy Metabolism - genetics
Fibronectin
Fibronectins - biosynthesis
Fibronectins - genetics
Gastric mucosa
Gastric Mucosa - growth & development
Gastric Mucosa - metabolism
Gene expression
Gene Expression Regulation
High fat diet
Homeostasis
Humans
Mucous membrane
Obesity - genetics
Obesity - metabolism
Obesity - pathology
Rats
Stomach
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Summary:The fibronectin type III domain-containing protein 5 (FNDC5) discovered in 2002 has recently gained attention due to its potential role in protecting against obesity. In rat, no data exist regarding FNDC5 production and regulation in the stomach. The aim of the present work was to determine the expression of FNDC5 in the rat stomach and its potential regulation by body composition. The present data shows FNDC5 gene expression in the gastric mucosa. Immunohistochemical studies found FNDC5 immunopositivity in chief cells of gastric tissue. By the use of three different antibodies FNDC5 was found expressed in gastric mucosa and secreted by the stomach. The rate of gastric FNDC5 secretion parallels the circulating levels of FNDC5. The body fat mass increase after intervention with high fat diet coincided with a decrease in the secretion of FNDC5 from the stomach and a diminution in the FNDC5 circulating levels. In summary, the present data shows, for the first time, the expression of FNDC5 in the stomach of rats and its regulation by body composition, suggesting a potential role of gastric FNDC5 in energy homeostasis.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep23067