Hepatogenous diabetes: Is it a neglected condition in chronic liver disease?

Diabetes mellitus(DM) that occurs because of chronic liver disease(CLD) is known as hepatogenous diabetes(HD). Although the association of diabetes and liver cirrhosis was described forty years ago, it was scarcely studied for long time. Patients suffering from this condition have low frequency of r...

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Published in:World journal of gastroenterology : WJG 2016-03, Vol.22 (10), p.2869-2874
Main Author: Diego García-Compeán José Alberto González-González Fernando Javier Lavalle-González Emmanuel Irineo González-Moreno Jesús Zacarías Villarreal-Pérez Héctor Jesús Maldonado-Garza
Format: Article
Language:English
Subjects:
Antiviral Agents - therapeutic use
Blood Glucose - drug effects
Blood Glucose - metabolism
Diabetes Mellitus - diagnosis
Diabetes Mellitus - drug therapy
Diabetes Mellitus - physiopathology
Diabetes Mellitus - virology
diabetes
Diabetes
disease
Glucose Tolerance Test
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - diagnosis
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - physiopathology
Hepatogenous
Humans
Hypoglycemic Agents - therapeutic use
liver
Liver Cirrhosis - diagnosis
Liver Cirrhosis - drug therapy
Liver Cirrhosis - physiopathology
Liver Cirrhosis - virology
mellitus
Outcomes
Therapy
Hepatitis
Predictive Value of Tests
Prognosis
Risk Factors
virus
Chronic
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Summary:Diabetes mellitus(DM) that occurs because of chronic liver disease(CLD) is known as hepatogenous diabetes(HD). Although the association of diabetes and liver cirrhosis was described forty years ago, it was scarcely studied for long time. Patients suffering from this condition have low frequency of risk factors of type 2 DM. Its incidence is higher in CLD of viral, alcoholic and cryptogenic etiology. Its pathophysiology relates to liver damage, pancreatic dysfunction, interactions between hepatitis C virus(HCV) and glucose metabolism mechanisms and genetic susceptibility. It associates with increased rate of liver complications and hepatocellular carcinoma, and decreased 5-year survival rate. It reduces sustained virological response in HCV infected patients. In spite of these evidences, the American Diabetes Association does not recognize HD. In addition, the impact of glucose control on clinical outcomes of patients has not been evaluated. Treatment of diabetes may be difficult due to liver insufficiency and hepatotoxicity of antidiabetic drugs. Notwithstanding, no therapeutic guidelines have been implemented up to date. In this editorial, authors discuss the reasons why they think that HD may be a neglected pathological condition and call attention to the necessity for more clinical research on different fields of this disease.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v22.i10.2869