Impact of non-oncological factors on tumor recurrence after liver transplantation in hepatocellular carcinoma patients

Hepatocellular carcinoma(HCC) is the most common primary neoplasm of the liver and is one of the leading causes of cancer-related death worldwide. Liver transplantation(LT) has become one of the best curative therapeutic options for patients with HCC, although tumor recurrence after LT is a major an...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2016-03, Vol.22 (9), p.2749-2759
Main Authors: Gu, Xiang-Qian, Zheng, Wei-Ping, Teng, Da-Hong, Sun, Ji-San, Zheng, Hong
Format: Article
Language:English
Subjects:
agents
Hepatocellular
Carcinoma, Hepatocellular - immunology
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Carcinoma, Hepatocellular - virology
carcinoma
Recurrence
Living
Comorbidity
donor
Dece
Hepatitis B - complications
Hepatitis C - complications
Humans
Immunocompromised Host
Immunosuppressive Agents - adverse effects
Liver
Liver Neoplasms - immunology
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Liver Neoplasms - virology
Liver Transplantation - adverse effects
Liver Transplantation - mortality
Neoplasm Recurrence, Local
Review
Risk Factors
transplantation
Immunosuppressive
Treatment Outcome
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Summary:Hepatocellular carcinoma(HCC) is the most common primary neoplasm of the liver and is one of the leading causes of cancer-related death worldwide. Liver transplantation(LT) has become one of the best curative therapeutic options for patients with HCC, although tumor recurrence after LT is a major and unaddressed cause of mortality. Furthermore, the factors that are associated with recurrence are not fully understood, and most previous studies have focused on the biological properties of HCC, such as the number and size of the HCC nodules, the degree of differentiation, the presence of hepatic vascular invasion, elevated serum levels of alpha-fetoprotein, and the tumor stage outside of the Milan criteria. Thus, little attention has been given to factors that are not directly related to HCC(i.e., "non-oncological factors"), which have emerged as predictors of tumor recurrence. This review was performed to assess the effects of nononcological factors on tumor recurrence after LT. The identification of these factors may provide new research directions and clinical strategies for the prophylaxis and surveillance of tumor recurrence after LT, which can help reduce recurrence and improve patient survival.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v22.i9.2749