Epigenetic regulation of insulin-like growth factor axis in hepatocellular carcinoma

The insulin-like growth factor(IGF) signaling path-way is an important pathway in the process of hepa-tocarcinogenesis,and the IGF network is clearly dysregulated in many cancers and developmental abnormalities.In hepatocellular carcinoma(HCC),only a minority of patients are eligible for curative tr...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2016-03, Vol.22 (9), p.2668-2677
Main Authors: El Tayebi, Hend Mohamed, Abdelaziz, Ahmed Ihab
Format: Article
Language:English
Subjects:
Animals
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
carcinoma
Insulin-like
DNA Methylation
Epigenesis, Genetic
factor
factors
Insulin-like
Gene Expression Regulation, Neoplastic
growth
Hepatocellular
Humans
Insulin-Like Growth Factor Binding Proteins - genetics
Insulin-Like Growth Factor Binding Proteins - metabolism
Liver Neoplasms - genetics
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
MicroRNAs - genetics
MicroRNAs - metabolism
Receptors, Somatomedin - genetics
Receptors, Somatomedin - metabolism
receptors
Epigenetic
Signal Transduction
Somatomedins - genetics
Somatomedins - metabolism
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Summary:The insulin-like growth factor(IGF) signaling path-way is an important pathway in the process of hepa-tocarcinogenesis,and the IGF network is clearly dysregulated in many cancers and developmental abnormalities.In hepatocellular carcinoma(HCC),only a minority of patients are eligible for curative treatments,such as tumor resection or liver transplant.Unfortunately,there is a high recurrence of HCC after surgical tumor removal.Recent research efforts have focused on targeting IGF axis members in an attempt to find therapeutic options for many health problems.In this review,we shed lights on the regulation of members of the IGF axis,mainly by micro RNAs in HCC.Micro RNAs in HCC attempt to halt the aberrant expression of the IGF network,and a single micro RNA can have multiple downstream targets in one or more signaling pathways.Targeting micro RNAs is a relatively new approach for identifying an efficient radical cure for HCC.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v22.i9.2668