Role of several histone lysine methyltransferases in tumor development

The field of cancer epigenetics has been evolving rapidly in recent decades. Epigenetic mechanisms include DNA methylation, histone modifications and microRNAs. Histone modifications are important markers of function and chromatin state. Aberrant histone methylation frequently occurs in tumor develo...

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Bibliographic Details
Published in:Biomedical reports 2016-03, Vol.4 (3), p.293-299
Main Authors: LI, JIFU, ZHU, SHUNQIN, KE, XIAO-XUE, CUI, HONGJUAN
Format: Article
Language:English
Subjects:
Aberration
Biological evolution
Cancer
Care and treatment
Cell growth
Cell migration
Cell proliferation
Chromatin
Deoxyribonucleic acid
Development and progression
Differentiation (biology)
DNA
DNA binding proteins
DNA methylation
Epigenetics
histone lysine methyltransferases
histone methylation
Histones
Lysine
Methyltransferases
miRNA
Review
Risk factors
tumor development
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Summary:The field of cancer epigenetics has been evolving rapidly in recent decades. Epigenetic mechanisms include DNA methylation, histone modifications and microRNAs. Histone modifications are important markers of function and chromatin state. Aberrant histone methylation frequently occurs in tumor development and progression. Multiple studies have identified that histone lysine methyltransferases regulate gene transcription through the methylation of histone, which affects cell proliferation and differentiation, cell migration and invasion, and other biological characteristics. Histones have variant lysine sites for different levels of methylation, catalyzed by different lysine methyltransferases, which have numerous effects on human cancers. The present review focused on the most recent advances, described the key function sites of histone lysine methyltransferases, integrated significant quantities of data to introduce several compelling histone lysine methyltransferases in various types of human cancers, summarized their role in tumor development and discussed their potential mechanisms of action.
ISSN:2049-9434
2049-9442
DOI:10.3892/br.2016.574