Reciprocal Changes of Circulating Long Non-Coding RNAs ZFAS1 and CDR1AS Predict Acute Myocardial Infarction

This study sought to evaluate the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers for acute myocardial infarction (AMI). We measured the circulating levels of 15 individual lncRNAs, known to be relevant to cardiovascular disease, using the whole blood samples collected from 103...

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Published in:Scientific reports 2016-03, Vol.6 (1), p.22384-22384, Article 22384
Main Authors: Zhang, Ying, Sun, Lihua, Xuan, Lina, Pan, Zhenwei, Li, Kang, Liu, Shuangshuang, Huang, Yuechao, Zhao, Xuyun, Huang, Lihua, Wang, Zhiguo, Hou, Yan, Li, Junnan, Tian, Ye, Yu, Jiahui, Han, Hui, Liu, Yanhong, Gao, Fei, Zhang, Yong, Wang, Shu, Du, Zhimin, Lu, Yanjie, Yang, Baofeng
Format: Article
Language:English
Subjects:
Animals
Antisense RNA
Biomarkers
Biomarkers - blood
Cardiac arrhythmia
Complementarity-determining region 1
Disease Models, Animal
Heart attacks
Humans
Mice
Mice, Inbred C57BL
Middle Aged
Myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - diagnosis
Prognosis
RNA, Long Noncoding - blood
Rodents
Zinc finger proteins
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Summary:This study sought to evaluate the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers for acute myocardial infarction (AMI). We measured the circulating levels of 15 individual lncRNAs, known to be relevant to cardiovascular disease, using the whole blood samples collected from 103 AMI patients, 149 non-AMI subjects, and 95 healthy volunteers. We found that only two of them, Zinc finger antisense 1 (ZFAS1) and Cdr1 antisense (CDR1AS), showed significant differential expression between AMI patients and control subjects. Circulating level of ZFAS1 was significantly lower in AMI (0.74 ± 0.07) than in non-AMI subjects (1.0 ± 0.05, P 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep22384