In vivo anti-plasmodial activities and toxic impacts of lime extract of a combination of Picralima nitida, Alstonia boonei and Gongronema latifolium in mice infected with Chloroquine-sensitive Plasmodium berghei

Lime extracts of powdered combination of seeds of Picralima nitida, stem bark of Alstonia boonei and leaves of Gongronema latifolium is a common remedy used in the treatment of malaria in South Western Nigeria. To determine the antiplasmodial activities of the combined herbal extracts and its impact...

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Bibliographic Details
Published in:African health sciences 2015-01, Vol.15 (4), p.1262-1270
Main Authors: Idowu, Emmanuel T, Ajaegbu, Henry Cn, Omotayo, Ahmed I, Aina, Oluwagbemiga O, Otubanjo, Olubunmi A
Format: Article
Language:English
Subjects:
Alstonia - chemistry
Animals
Antimalarials
Antimalarials - chemistry
Antimalarials - isolation & purification
Antimalarials - pharmacology
Apocynaceae - chemistry
Calcium Compounds
Chloroquine
Dose-Response Relationship, Drug
Drug Combinations
Hematology
Herbal medicine
Kidney - drug effects
Liver - drug effects
Malaria
Malaria - drug therapy
Malaria - parasitology
Medical treatment
Medicinal plants
Meliaceae - chemistry
Mice
Nigeria
Oxides
Parasitology
Phytotherapy
Plant Bark - chemistry
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Extracts - toxicity
Plant Leaves - chemistry
Plants, Medicinal
Plasmodium berghei - drug effects
Research methodology
Rodents
Seeds - chemistry
Statistical analysis
Toxicity Tests
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Summary:Lime extracts of powdered combination of seeds of Picralima nitida, stem bark of Alstonia boonei and leaves of Gongronema latifolium is a common remedy used in the treatment of malaria in South Western Nigeria. To determine the antiplasmodial activities of the combined herbal extracts and its impact on the haematological, hepatological and renological parameters in mice. The 4-day suppressive and curative tests were used to assess the antiplasmodial activities of the extract in mice infected with chloroquine-sensitive Plasmodium berghei at concentration of 200mg/kg, 400mg/kg and 800mg/kg body weight. The haematological parameters including red blood cells, white blood cells, packed cell volume and haemoglobin count were analysed with an auto analyser. The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were determined, while urea, protein and creatinine were analysed by standard procedural methods. The 4-day suppressive test revealed that the test extract achieved percentage suppression of 39.0%, 41.6% and 54.68% for the 200mg/kg, 400mg/kg and 800mg/kg concentration respectively. Additionally, the curative test achieved a high percentage suppression of 80.97%, 83.84% and 86.16% at the 200mg/kg, 400mg/kg and 800mg/kg concentration respectively. The extracts did not induce significant change on haematological parameters (P>0.05), while significant elevation in the values of the ALT and AST (P
ISSN:1680-6905
1729-0503
1680-6905
DOI:10.4314/ahs.v15i4.27