Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality: The Hordaland Health Study

We aimed to evaluate 10 biomarkers related to inflammation and the kynurenine pathway, including neopterin, kynurenine:tryptophan ratio, C-reactive protein, tryptophan, and 6 kynurenines, as potential predictors of all-cause and cause-specific mortality in a general population sample. The study coho...

Full description

Saved in:
Bibliographic Details
Published in:American journal of epidemiology 2016-02, Vol.183 (4), p.249-258
Main Authors: Zuo, Hui, Ueland, Per M, Ulvik, Arve, Eussen, Simone J P M, Vollset, Stein E, Nygård, Ottar, Midttun, Øivind, Theofylaktopoulou, Despoina, Meyer, Klaus, Tell, Grethe S
Format: Article
Language:English
Subjects:
Aged
Biomarkers
Biomarkers - blood
C-Reactive Protein - metabolism
Cancer
Cardiovascular disease
Female
Humans
Inflammation
Inflammation - blood
Kynurenine - blood
Longitudinal Studies
Male
Metabolites
Middle Aged
Mortality
Neopterin - blood
Norway
ORIGINAL CONTRIBUTIONS
Plasma
Tryptophan - blood
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We aimed to evaluate 10 biomarkers related to inflammation and the kynurenine pathway, including neopterin, kynurenine:tryptophan ratio, C-reactive protein, tryptophan, and 6 kynurenines, as potential predictors of all-cause and cause-specific mortality in a general population sample. The study cohort was participants involved in a community-based Norwegian study, the Hordaland Health Study (HUSK). We used Cox proportional hazards models to assess associations of the biomarkers with all-cause mortality and competing-risk models for cause-specific mortality. Of the 7,015 participants, 1,496 deaths were recorded after a median follow-up time of 14 years (1998-2012). Plasma levels of inflammatory markers (neopterin, kynurenine:tryptophan ratio, and C-reactive protein), anthranilic acid, and 3-hydroxykynurenine were positively associated with all-cause mortality, and tryptophan and xanthurenic acid were inversely associated. Multivariate-adjusted hazard ratios for the highest (versus lowest) quartiles of the biomarkers were 1.19-1.60 for positive associations and 0.73-0.87 for negative associations. All of the inflammatory markers and most kynurenines, except kynurenic acid and 3-hydroxyanthranilic acid, were associated with cardiovascular disease (CVD) mortality. In this general population, plasma biomarkers of inflammation and kynurenines were associated with risk of all-cause, cancer, and CVD mortality. Associations were stronger for CVD mortality than for mortality due to cancer or other causes.
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwv242