Chiba study of Mother and Children's Health (C-MACH): cohort study with omics analyses

PurposeRecent epidemiological studies have shown that environmental factors during the fetal period to early childhood might affect the risk of non-communicable diseases in adulthood. This is referred to as the developmental origins of health and disease (DOHaD) concept. The Chiba study of Mother an...

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Bibliographic Details
Published in:BMJ open 2016-01, Vol.6 (1), p.e010531
Main Authors: Sakurai, Kenichi, Miyaso, Hidenobu, Eguchi, Akifumi, Matsuno, Yoshiharu, Yamamoto, Midori, Todaka, Emiko, Fukuoka, Hideoki, Hata, Akira, Mori, Chisato
Format: Article
Language:English
Subjects:
Biomarkers
Biomarkers - metabolism
Child Health - statistics & numerical data
Child, Preschool
Children & youth
Childrens health
Chronic illnesses
Consent
Developmental Disabilities - epidemiology
Disease
DNA methylation
Environmental Pollutants - analysis
Epigenesis, Genetic - physiology
Epigenetics
Female
Fetal Blood - chemistry
Follow-Up Studies
Gastrointestinal Microbiome - physiology
Gene-Environment Interaction
Genomes
Genomics - methods
Hospitals
Humans
Infant
Infant, Newborn
Japan - epidemiology
Maternal Exposure - statistics & numerical data
Maternal Health - statistics & numerical data
Metabolites
Metabolome - physiology
Metabolomics - methods
Microbiota
Mothers
Obesity
Participation
Polychlorinated Biphenyls - analysis
Population
Pregnancy
Pregnancy Complications - epidemiology
Prenatal Exposure Delayed Effects - epidemiology
Prenatal Nutritional Physiological Phenomena
Prognosis
Prospective Studies
Public Health
Sample size
Womens health
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Summary:PurposeRecent epidemiological studies have shown that environmental factors during the fetal period to early childhood might affect the risk of non-communicable diseases in adulthood. This is referred to as the developmental origins of health and disease (DOHaD) concept. The Chiba study of Mother and Children's Health (C-MACH) is a birth cohort study based on the DOHaD hypothesis and involves multiomics analysis. This study aims to explore the effects of genetic and environmental factors—particularly the fetal environment and postbirth living environment—on children's health, and to identify potential biomarkers for these effects.ParticipantsThe C-MACH consists of three hospital-based cohorts. The study participants are pregnant women at
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2015-010531