Myosteatosis increases with aging and is associated with incident diabetes in African ancestry men

Objective Skeletal muscle fat infiltration (known as myosteatosis) is greater in African compared with European ancestry men and may play an important role in the development of type 2 diabetes (T2D). However, prospective studies examining the magnitude of changes in myosteatosis with aging and thei...

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Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2016-02, Vol.24 (2), p.476-482
Main Authors: Miljkovic, Iva, Kuipers, Allison L., Cvejkus, Ryan, Bunker, Clareann H., Patrick, Alan L., Gordon, Christopher L., Zmuda, Joseph M.
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Adipose Tissue - pathology
Adult
African Continental Ancestry Group
Age
Aged
Aging
Aging - metabolism
Body Weight
Diabetes
Diabetes Mellitus, Type 2 - ethnology
Diabetes Mellitus, Type 2 - etiology
European Continental Ancestry Group
Genealogy
Health facilities
Humans
Insulin
Insulin resistance
Leg
Longitudinal Studies
Male
Mens health
Metabolism
Middle age
Middle Aged
Muscle, Skeletal - pathology
Muscular Diseases - complications
Muscular Diseases - ethnology
Muscular Diseases - pathology
Musculoskeletal system
Oxidation
Prospective Studies
Studies
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Summary:Objective Skeletal muscle fat infiltration (known as myosteatosis) is greater in African compared with European ancestry men and may play an important role in the development of type 2 diabetes (T2D). However, prospective studies examining the magnitude of changes in myosteatosis with aging and their metabolic consequences are sparse. Methods Longitudinal changes in peripheral quantitative computed tomography measured calf myosteatosis [intermuscular fat (mm2) and skeletal muscle density as a measure of intramuscular fat (mg/cm3)] were examined in 1515 Afro‐Caribbean men aged 40+ years recruited without regard to their health status. Results During an average of 6.2 years of follow‐up, an age‐related increase in intermuscular fat and a decrease in skeletal muscle density were observed (all P 
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.21328