Dietary Nitrate Lowers Blood Pressure: Epidemiological, Pre-clinical Experimental and Clinical Trial Evidence

Nitric oxide (NO), a potent vasodilator critical in maintaining vascular homeostasis, can reduce blood pressure in vivo. Loss of constitutive NO generation, for example as a result of endothelial dysfunction, occurs in many pathological conditions, including hypertension, and contributes to disease...

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Bibliographic Details
Published in:Current Hypertension Reports 2016-02, Vol.18 (2), p.17-17, Article 17
Main Authors: Gee, Lorna C., Ahluwalia, Amrita
Format: Article
Language:English
Subjects:
Animals
Blood Pressure - drug effects
Cardiology
Clinical Trials as Topic
Diet
Drug Evaluation, Preclinical
Family Medicine
General Practice
Humans
Hypertension
Hypertension - physiopathology
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Nephrology
Nitrates - pharmacology
Pathogenesis of Hypertension (W Elliott
Pathogenesis of Hypertension (W Elliott, Section Editor)
Primary Care Medicine
Section Editor
Topical Collection on Pathogenesis of Hypertension
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Summary:Nitric oxide (NO), a potent vasodilator critical in maintaining vascular homeostasis, can reduce blood pressure in vivo. Loss of constitutive NO generation, for example as a result of endothelial dysfunction, occurs in many pathological conditions, including hypertension, and contributes to disease pathology. Attempts to therapeutically deliver NO via organic nitrates (e.g. glyceryl trinitrate, GTN) to reduce blood pressure in hypertensives have been largely unsuccessful. However, in recent years inorganic (or ‘dietary’) nitrate has been identified as a potential solution for NO delivery through its sequential chemical reduction via the enterosalivary circuit. With dietary nitrate found in abundance in vegetables this review discusses epidemiological, pre-clinical and clinical data supporting the idea that dietary nitrate could represent a cheap and effective dietary intervention capable of reducing blood pressure and thereby improving cardiovascular health.
ISSN:1522-6417
1534-3111
DOI:10.1007/s11906-015-0623-4