Resveratrol suppresses human glioblastoma cell migration and invasion via activation of RhoA/ROCK signaling pathway

Numerous studies have demonstrated that resveratrol has a potential use in cancer prevention and treatment. However, the effects of resveratrol on cancer cell motility and invasiveness remain unclear. The current study aimed to examine the effects of resveratrol on cell migration and invasion in hum...

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Bibliographic Details
Published in:Oncology letters 2016-01, Vol.11 (1), p.484-490
Main Authors: XIONG, WEI, YIN, ANAN, MAO, XINGGANG, ZHANG, WEI, HUANG, HUIYONG, ZHANG, XIANG
Format: Article
Language:English
Subjects:
Analysis
Apoptosis
Biotechnology
Brain cancer
Care and treatment
Cell adhesion & migration
Cell culture
Cell migration
Cellular signal transduction
Cytoskeleton
Development and progression
glioblastoma
Glioblastoma multiforme
Health aspects
invasion
Medical prognosis
migration
Motility
Resveratrol
RhoA
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Summary:Numerous studies have demonstrated that resveratrol has a potential use in cancer prevention and treatment. However, the effects of resveratrol on cancer cell motility and invasiveness remain unclear. The current study aimed to examine the effects of resveratrol on cell migration and invasion in human glioblastoma cells, and to explore the underlying molecular mechanisms. In wound-healing and Matrigel transwell assays, resveratrol was found to significantly inhibit the migration and invasion of U87MG, T98G and U251 glioblastoma cells in vitro. Results from western blot analysis and gelatin zymography revealed that resveratrol also suppressed the expression and activity of matrix metalloproteinase 2 (MMP-2; P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2015.3888