The functions of TRPP2 in the vascular system

TRPP2 （polycystin-2, PC2 or PKD2）, encoded by the PKD2 gene, is a non-selective cation channel with a large single channel conductance and high Ca2＋ permeability. In cell membrane, TRPP2, along with polycystin-1, TRPV4 and TRPCl, functions as a mechanotransduction channel. In the endoplasmic reticul...

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Bibliographic Details
Published in:Acta pharmacologica Sinica 2016-01, Vol.37 (1), p.13-18
Main Authors: Du, Juan, Fu, Jie, Xia, Xian-ming, Shen, Bing
Format: Article
Language:English
Subjects:
Animals
Blood Pressure - physiology
Blood Vessels - physiology
Calcium - metabolism
Endothelium, Vascular - physiology
Homeostasis
Humans
Intracellular Space - metabolism
Muscle, Smooth, Vascular - physiology
Mutation
Review
TRPP Cation Channels - agonists
TRPP Cation Channels - antagonists & inhibitors
TRPP Cation Channels - genetics
TRPP Cation Channels - physiology
制剂
处方
药学
药理
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Summary:TRPP2 （polycystin-2, PC2 or PKD2）, encoded by the PKD2 gene, is a non-selective cation channel with a large single channel conductance and high Ca2＋ permeability. In cell membrane, TRPP2, along with polycystin-1, TRPV4 and TRPCl, functions as a mechanotransduction channel. In the endoplasmic reticulum, TRPP2 modulates intracellular Ca2＋ release associated with IP3 receptors and the ryanodine receptors. Noteworthily, TRPP2 is widely expressed in vascular endothelial and smooth muscle cells of all major vascular beds, and contributes to the regulation of vessel function. The mutation of the PKD2 gene is a major cause of autosomal dominant polycystic kidney disease （ADPKD）, which is not only a common genetic disease of the kidney but also a systemic disorder associated with abnormalities in the vasculature; cardiovascular complications are the leading cause of mortality and morbidity in ADPKD patients. This review provides an overview of the current knowledge regarding the TRPP2 protein and its possible role in cardiovascular function and related diseases.
ISSN:1671-4083
1745-7254
DOI:10.1038/aps.2015.126