Abnormal function of platelets and role of angelica sinensis in patients with ulcerative colitis

AIM:To explore the abnormal function of platelets and the role of angelica sinensis injection (ASI) in patients with ulcerative colitis (UC).METHODS:In 39 patients with active UC, 25 patients with remissive UC and 30 healthy people, α-granule membrane protein (GMP-140) and thromboxane B2 (TXB2) were...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2004-02, Vol.10 (4), p.606-609
Main Authors: Dong, Wei-Guo, Liu, Shao-Ping, Zhu, Hai-Hang, Luo, He-Sheng, Yu, Jie-Ping
Format: Article
Language:English
Subjects:
Adult
Aged
Angelica sinensis
Blood Platelets - drug effects
Blood Platelets - physiology
Brief Reports
Colitis, Ulcerative - drug therapy
Colitis, Ulcerative - physiopathology
Female
Humans
Male
Middle Aged
Phytotherapy
Plant Preparations - administration & dosage
Platelet Aggregation - drug effects
Platelet Aggregation - physiology
凝血噁烷B2
当归注射液
溃疡性大肠炎
药理作用
血小板
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Summary:AIM:To explore the abnormal function of platelets and the role of angelica sinensis injection (ASI) in patients with ulcerative colitis (UC).METHODS:In 39 patients with active UC, 25 patients with remissive UC and 30 healthy people, α-granule membrane protein (GMP-140) and thromboxane B2 (TXB2) were detected by means of ELISA, 6-keto-PGF1α was detected by radioimmunoassay, platelet count (PC) and 1min platelet aggregation rate (1min PAR) were detected by blood automatic tester and platelet aggregation tester respectively,and von Willebrand factor related antigen (vWF:Ag) was detected by the means of monoclonal-ELISA. The 64 patients with UC were divided into two therapy groups. After routine treatment and angelica sinensis injection (ASI)+routine treatment respectively for 3 weeks, all these parameters were also detected.RESULTS:The PC, 1min PAR and levels of GMP-140,TXB2, and vWF:Ag in active UC were significanrly higher than those in remissive UC and normal controls (P
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v10.i4.606