Atrial Cardiopathy and Cryptogenic Stroke: A Cross-sectional Pilot Study

Background There is increasing evidence that left atrial dysfunction or cardiopathy is associated with ischemic stroke risk independently of atrial fibrillation. We aimed to determine the prevalence of atrial cardiopathy biomarkers in patients with cryptogenic stroke. Methods We included consecutive...

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Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2016-01, Vol.25 (1), p.110-114
Main Authors: Yaghi, Shadi, MD, Boehme, Amelia K., PhD, Hazan, Rebecca, MS, Hod, Eldad A., MD, Canaan, Alberto, BS, Andrews, Howard F., PhD, Kamel, Hooman, MD, Marshall, Randolph S., MD, MS, Elkind, Mitchell S.V., MD, MS
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
anticoagulant
atrial cardiopathy
Atrial Fibrillation - epidemiology
Atrial Function, Left - physiology
Biomarkers
Brain Ischemia - epidemiology
Brain Ischemia - physiopathology
Cardiomegaly - blood
Cardiomegaly - diagnostic imaging
Cardiomegaly - epidemiology
Cardiomegaly - physiopathology
Cardiovascular
Comorbidity
Coronary Disease - epidemiology
Cross-Sectional Studies
cryptogenic
Electrocardiography
Female
Foramen Ovale, Patent - epidemiology
Heart Diseases - blood
Heart Diseases - diagnostic imaging
Heart Diseases - epidemiology
Heart Diseases - physiopathology
Humans
Hyperlipidemias - epidemiology
Hypertension - epidemiology
Kidney Diseases - epidemiology
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Neurology
Peptide Fragments - blood
Pilot Projects
Prevalence
prevention
Prospective Studies
Registries
Smoking - epidemiology
Stroke
Ultrasonography
Young Adult
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Summary:Background There is increasing evidence that left atrial dysfunction or cardiopathy is associated with ischemic stroke risk independently of atrial fibrillation. We aimed to determine the prevalence of atrial cardiopathy biomarkers in patients with cryptogenic stroke. Methods We included consecutive patients with ischemic stroke enrolled in the New York Columbia Collaborative Specialized Program of Translational Research in Acute Stroke registry between December 1, 2008, and April 30, 2012. Medical records were reviewed and patients with a diagnosis of cryptogenic stroke were identified. Atrial cardiopathy was defined as at least one of the following: serum N-terminal probrain natriuretic peptide (NT-proBNP) level greater than 250 pg/mL, P -wave terminal force velocity in lead V1 (PTFV1) on electrocardiogram (ECG) greater than 5000 µV⋅ms, or severe left atrial enlargement (LAE) on echocardiogram. We compared clinical, echocardiographic, and radiological characteristics between patients with and without atrial cardiopathy. Results Among 40 patients with cryptogenic stroke, 63% had at least one of the biomarkers of atrial cardiopathy; 49% had elevated NT-proBNP levels, 20% had evidence of increased PTFV1 on ECG, and 5% had severe LAE. Patients with atrial cardiopathy were more likely to be older (76 versus 62 years, P  = .012); have hypertension (96% versus 33%, P  
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2015.09.001