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GPRC6a is not required for the effects of a high‐protein diet on body weight in mice
Objective The G‐protein coupled receptor family C group 6 member A (GPRC6A) is activated by proteinogenic amino acids and may sense amino acids in the gastrointestinal tract and the brain. The study investigated whether GPRC6A was necessary for the effects of low‐ and high‐protein diets on body weig...
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| Published in: | Obesity (Silver Spring, Md.) Md.), 2015-06, Vol.23 (6), p.1194-1200 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c5133-9572f82f2285e0f49bfe94e5a1c07e680011cb062618ce6086b7c9b4b8a7667d3 |
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| cites | cdi_FETCH-LOGICAL-c5133-9572f82f2285e0f49bfe94e5a1c07e680011cb062618ce6086b7c9b4b8a7667d3 |
| container_end_page | 1200 |
| container_issue | 6 |
| container_start_page | 1194 |
| container_title | Obesity (Silver Spring, Md.) |
| container_volume | 23 |
| creator | Kinsey‐Jones, James S. Alamshah, Amin McGavigan, Anne K. Spreckley, Eleanor Banks, Katherine Cereceda Monteoliva, Nicholas Norton, Mariana Bewick, Gavin A. Murphy, Kevin G. |
| description | Objective
The G‐protein coupled receptor family C group 6 member A (GPRC6A) is activated by proteinogenic amino acids and may sense amino acids in the gastrointestinal tract and the brain. The study investigated whether GPRC6A was necessary for the effects of low‐ and high‐protein diets on body weight and food intake in mice.
Methods
The role of GPRC6A in mediating the effects of a low‐protein diet on body weight was investigated in GPRC6a knockout (GPRC6a‐KO) and wild‐type (WT) mice fed a control diet (18% protein) or a low‐protein diet (6% protein) for 9 days. The role of GPRC6A in mediating the effects of a high‐protein diet on body weight was investigated in GPRC6a‐KO and WT mice fed a control diet (18% protein) or a high‐protein diet (50% protein) for 5 weeks.
Results
A high‐protein diet reduced body weight gain and food intake compared with a control diet in both WT and GPRC6a‐KO mice. A low‐protein diet decreased body weight gain in GPRC6a‐KO mice.
Conclusions
GPRC6A was not necessary for the effects of a low‐ or high‐protein diet on body weight and likely does not play a role in protein‐induced satiety. |
| doi_str_mv | 10.1002/oby.21083 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4692088</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3711951121</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5133-9572f82f2285e0f49bfe94e5a1c07e680011cb062618ce6086b7c9b4b8a7667d3</originalsourceid><addsrcrecordid>eNp1kc1qVDEUx4Mo9kMXvoAE3NjFtPm4-doIddAqFFpERVchN_ekk3LnZprca5mdj9Bn7JOYOnVQoasccn78OOf8EXpBySElhB2ldn3IKNH8EdqlhpOZ4ubb422t6Q7aK-WSkEYSQZ-iHSaM0FroXfT15PzTXDocCx7SiDNcTTFDh0PKeFwAhhDAjwWngB1exIvF7c-bVU4jxAF3EUacBtymbo2voTZHXL-X0cMz9CS4vsDz-3cffXn_7vP8w-z07OTj_Ph05gXlfGaEYkGzwJgWQEJj2gCmAeGoJwqkJoRS3xLJJNUeJNGyVd60TaudklJ1fB-92XhXU7uEzsMwZtfbVY5Ll9c2uWj_7QxxYS_SD9tIw4jWVfD6XpDT1QRltMtYPPS9GyBNxVKpuRJGc17RV_-hl2nKQ13vjqonp0o1lTrYUD6nUjKE7TCU2Lu0bE3L_k6rsi__nn5L_omnAkcb4Dr2sH7YZM_eft8ofwFJFZ5w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1687391774</pqid></control><display><type>article</type><title>GPRC6a is not required for the effects of a high‐protein diet on body weight in mice</title><source>Wiley</source><creator>Kinsey‐Jones, James S. ; Alamshah, Amin ; McGavigan, Anne K. ; Spreckley, Eleanor ; Banks, Katherine ; Cereceda Monteoliva, Nicholas ; Norton, Mariana ; Bewick, Gavin A. ; Murphy, Kevin G.</creator><creatorcontrib>Kinsey‐Jones, James S. ; Alamshah, Amin ; McGavigan, Anne K. ; Spreckley, Eleanor ; Banks, Katherine ; Cereceda Monteoliva, Nicholas ; Norton, Mariana ; Bewick, Gavin A. ; Murphy, Kevin G.</creatorcontrib><description>Objective
The G‐protein coupled receptor family C group 6 member A (GPRC6A) is activated by proteinogenic amino acids and may sense amino acids in the gastrointestinal tract and the brain. The study investigated whether GPRC6A was necessary for the effects of low‐ and high‐protein diets on body weight and food intake in mice.
Methods
The role of GPRC6A in mediating the effects of a low‐protein diet on body weight was investigated in GPRC6a knockout (GPRC6a‐KO) and wild‐type (WT) mice fed a control diet (18% protein) or a low‐protein diet (6% protein) for 9 days. The role of GPRC6A in mediating the effects of a high‐protein diet on body weight was investigated in GPRC6a‐KO and WT mice fed a control diet (18% protein) or a high‐protein diet (50% protein) for 5 weeks.
Results
A high‐protein diet reduced body weight gain and food intake compared with a control diet in both WT and GPRC6a‐KO mice. A low‐protein diet decreased body weight gain in GPRC6a‐KO mice.
Conclusions
GPRC6A was not necessary for the effects of a low‐ or high‐protein diet on body weight and likely does not play a role in protein‐induced satiety.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.21083</identifier><identifier>PMID: 25958858</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Amino acids ; Animals ; Binding sites ; Body Weight - drug effects ; Diet ; Dietary Proteins - administration & dosage ; Food ; Homeostasis ; Male ; Metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Original ; Peptides ; Physiology ; Proteins ; Receptors, G-Protein-Coupled - metabolism ; Rodents ; Studies ; Weight control ; Weight Gain - drug effects</subject><ispartof>Obesity (Silver Spring, Md.), 2015-06, Vol.23 (6), p.1194-1200</ispartof><rights>2015 The Authors. Obesity published by Wiley Periodicals, Inc. on behalf of The Obesity Society (TOS).</rights><rights>2015 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Jun 2015</rights><rights>2015 The Obesity Society 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5133-9572f82f2285e0f49bfe94e5a1c07e680011cb062618ce6086b7c9b4b8a7667d3</citedby><cites>FETCH-LOGICAL-c5133-9572f82f2285e0f49bfe94e5a1c07e680011cb062618ce6086b7c9b4b8a7667d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.21083$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.21083$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,315,786,790,891,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25958858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kinsey‐Jones, James S.</creatorcontrib><creatorcontrib>Alamshah, Amin</creatorcontrib><creatorcontrib>McGavigan, Anne K.</creatorcontrib><creatorcontrib>Spreckley, Eleanor</creatorcontrib><creatorcontrib>Banks, Katherine</creatorcontrib><creatorcontrib>Cereceda Monteoliva, Nicholas</creatorcontrib><creatorcontrib>Norton, Mariana</creatorcontrib><creatorcontrib>Bewick, Gavin A.</creatorcontrib><creatorcontrib>Murphy, Kevin G.</creatorcontrib><title>GPRC6a is not required for the effects of a high‐protein diet on body weight in mice</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
The G‐protein coupled receptor family C group 6 member A (GPRC6A) is activated by proteinogenic amino acids and may sense amino acids in the gastrointestinal tract and the brain. The study investigated whether GPRC6A was necessary for the effects of low‐ and high‐protein diets on body weight and food intake in mice.
Methods
The role of GPRC6A in mediating the effects of a low‐protein diet on body weight was investigated in GPRC6a knockout (GPRC6a‐KO) and wild‐type (WT) mice fed a control diet (18% protein) or a low‐protein diet (6% protein) for 9 days. The role of GPRC6A in mediating the effects of a high‐protein diet on body weight was investigated in GPRC6a‐KO and WT mice fed a control diet (18% protein) or a high‐protein diet (50% protein) for 5 weeks.
Results
A high‐protein diet reduced body weight gain and food intake compared with a control diet in both WT and GPRC6a‐KO mice. A low‐protein diet decreased body weight gain in GPRC6a‐KO mice.
Conclusions
GPRC6A was not necessary for the effects of a low‐ or high‐protein diet on body weight and likely does not play a role in protein‐induced satiety.</description><subject>Amino acids</subject><subject>Animals</subject><subject>Binding sites</subject><subject>Body Weight - drug effects</subject><subject>Diet</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Food</subject><subject>Homeostasis</subject><subject>Male</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Original</subject><subject>Peptides</subject><subject>Physiology</subject><subject>Proteins</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Rodents</subject><subject>Studies</subject><subject>Weight control</subject><subject>Weight Gain - drug effects</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp1kc1qVDEUx4Mo9kMXvoAE3NjFtPm4-doIddAqFFpERVchN_ekk3LnZprca5mdj9Bn7JOYOnVQoasccn78OOf8EXpBySElhB2ldn3IKNH8EdqlhpOZ4ubb422t6Q7aK-WSkEYSQZ-iHSaM0FroXfT15PzTXDocCx7SiDNcTTFDh0PKeFwAhhDAjwWngB1exIvF7c-bVU4jxAF3EUacBtymbo2voTZHXL-X0cMz9CS4vsDz-3cffXn_7vP8w-z07OTj_Ph05gXlfGaEYkGzwJgWQEJj2gCmAeGoJwqkJoRS3xLJJNUeJNGyVd60TaudklJ1fB-92XhXU7uEzsMwZtfbVY5Ll9c2uWj_7QxxYS_SD9tIw4jWVfD6XpDT1QRltMtYPPS9GyBNxVKpuRJGc17RV_-hl2nKQ13vjqonp0o1lTrYUD6nUjKE7TCU2Lu0bE3L_k6rsi__nn5L_omnAkcb4Dr2sH7YZM_eft8ofwFJFZ5w</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Kinsey‐Jones, James S.</creator><creator>Alamshah, Amin</creator><creator>McGavigan, Anne K.</creator><creator>Spreckley, Eleanor</creator><creator>Banks, Katherine</creator><creator>Cereceda Monteoliva, Nicholas</creator><creator>Norton, Mariana</creator><creator>Bewick, Gavin A.</creator><creator>Murphy, Kevin G.</creator><general>Blackwell Publishing Ltd</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201506</creationdate><title>GPRC6a is not required for the effects of a high‐protein diet on body weight in mice</title><author>Kinsey‐Jones, James S. ; Alamshah, Amin ; McGavigan, Anne K. ; Spreckley, Eleanor ; Banks, Katherine ; Cereceda Monteoliva, Nicholas ; Norton, Mariana ; Bewick, Gavin A. ; Murphy, Kevin G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5133-9572f82f2285e0f49bfe94e5a1c07e680011cb062618ce6086b7c9b4b8a7667d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Amino acids</topic><topic>Animals</topic><topic>Binding sites</topic><topic>Body Weight - drug effects</topic><topic>Diet</topic><topic>Dietary Proteins - administration & dosage</topic><topic>Food</topic><topic>Homeostasis</topic><topic>Male</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Original</topic><topic>Peptides</topic><topic>Physiology</topic><topic>Proteins</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Rodents</topic><topic>Studies</topic><topic>Weight control</topic><topic>Weight Gain - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kinsey‐Jones, James S.</creatorcontrib><creatorcontrib>Alamshah, Amin</creatorcontrib><creatorcontrib>McGavigan, Anne K.</creatorcontrib><creatorcontrib>Spreckley, Eleanor</creatorcontrib><creatorcontrib>Banks, Katherine</creatorcontrib><creatorcontrib>Cereceda Monteoliva, Nicholas</creatorcontrib><creatorcontrib>Norton, Mariana</creatorcontrib><creatorcontrib>Bewick, Gavin A.</creatorcontrib><creatorcontrib>Murphy, Kevin G.</creatorcontrib><collection>Wiley-Blackwell Open Access Collection</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kinsey‐Jones, James S.</au><au>Alamshah, Amin</au><au>McGavigan, Anne K.</au><au>Spreckley, Eleanor</au><au>Banks, Katherine</au><au>Cereceda Monteoliva, Nicholas</au><au>Norton, Mariana</au><au>Bewick, Gavin A.</au><au>Murphy, Kevin G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GPRC6a is not required for the effects of a high‐protein diet on body weight in mice</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2015-06</date><risdate>2015</risdate><volume>23</volume><issue>6</issue><spage>1194</spage><epage>1200</epage><pages>1194-1200</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><notes>The section is funded by grants from the MRC, BBSRC, and NIHR, an Integrative Mammalian Biology (IMB) Capacity Building Award, an FP7‐HEALTH‐2009‐241592 EuroCHIP grant, and the NIHR Imperial Biomedical Research Centre Funding Scheme. JKJ and KGM are funded by BBSRC project grant BB/I001816/1. NCM was funded by a British Society for Neuroendocrinology Student Summer Laboratory Experience Grant. MN was funded by a Society for Endocrinology Summer Studentship.</notes><notes>The authors declared no conflict of interest.</notes><notes>Disclosure</notes><notes>Funding agencies</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Additional Supporting Information may be found in the online version of this article.</notes><notes>Funding agencies: The section is funded by grants from the MRC, BBSRC, and NIHR, an Integrative Mammalian Biology (IMB) Capacity Building Award, an FP7-HEALTH-2009-241592 EuroCHIP grant, and the NIHR Imperial Biomedical Research Centre Funding Scheme. JKJ and KGM are funded by BBSRC project grant BB/I001816/1. NCM was funded by a British Society for Neuroendocrinology Student Summer Laboratory Experience Grant. MN was funded by a Society for Endocrinology Summer Studentship.</notes><notes>Disclosure: The authors declared no conflict of interest.</notes><abstract>Objective
The G‐protein coupled receptor family C group 6 member A (GPRC6A) is activated by proteinogenic amino acids and may sense amino acids in the gastrointestinal tract and the brain. The study investigated whether GPRC6A was necessary for the effects of low‐ and high‐protein diets on body weight and food intake in mice.
Methods
The role of GPRC6A in mediating the effects of a low‐protein diet on body weight was investigated in GPRC6a knockout (GPRC6a‐KO) and wild‐type (WT) mice fed a control diet (18% protein) or a low‐protein diet (6% protein) for 9 days. The role of GPRC6A in mediating the effects of a high‐protein diet on body weight was investigated in GPRC6a‐KO and WT mice fed a control diet (18% protein) or a high‐protein diet (50% protein) for 5 weeks.
Results
A high‐protein diet reduced body weight gain and food intake compared with a control diet in both WT and GPRC6a‐KO mice. A low‐protein diet decreased body weight gain in GPRC6a‐KO mice.
Conclusions
GPRC6A was not necessary for the effects of a low‐ or high‐protein diet on body weight and likely does not play a role in protein‐induced satiety.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25958858</pmid><doi>10.1002/oby.21083</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1930-7381 |
| ispartof | Obesity (Silver Spring, Md.), 2015-06, Vol.23 (6), p.1194-1200 |
| issn | 1930-7381 1930-739X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4692088 |
| source | Wiley |
| subjects | Amino acids Animals Binding sites Body Weight - drug effects Diet Dietary Proteins - administration & dosage Food Homeostasis Male Metabolism Mice Mice, Inbred C57BL Mice, Knockout Original Peptides Physiology Proteins Receptors, G-Protein-Coupled - metabolism Rodents Studies Weight control Weight Gain - drug effects |
| title | GPRC6a is not required for the effects of a high‐protein diet on body weight in mice |
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