GPRC6a is not required for the effects of a high‐protein diet on body weight in mice

Objective The G‐protein coupled receptor family C group 6 member A (GPRC6A) is activated by proteinogenic amino acids and may sense amino acids in the gastrointestinal tract and the brain. The study investigated whether GPRC6A was necessary for the effects of low‐ and high‐protein diets on body weig...

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Published in:Obesity (Silver Spring, Md.) Md.), 2015-06, Vol.23 (6), p.1194-1200
Main Authors: Kinsey‐Jones, James S., Alamshah, Amin, McGavigan, Anne K., Spreckley, Eleanor, Banks, Katherine, Cereceda Monteoliva, Nicholas, Norton, Mariana, Bewick, Gavin A., Murphy, Kevin G.
Format: Article
Language:English
Subjects:
Amino acids
Animals
Binding sites
Body Weight - drug effects
Diet
Dietary Proteins - administration & dosage
Food
Homeostasis
Male
Metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Original
Peptides
Physiology
Proteins
Receptors, G-Protein-Coupled - metabolism
Rodents
Studies
Weight control
Weight Gain - drug effects
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Summary:Objective The G‐protein coupled receptor family C group 6 member A (GPRC6A) is activated by proteinogenic amino acids and may sense amino acids in the gastrointestinal tract and the brain. The study investigated whether GPRC6A was necessary for the effects of low‐ and high‐protein diets on body weight and food intake in mice. Methods The role of GPRC6A in mediating the effects of a low‐protein diet on body weight was investigated in GPRC6a knockout (GPRC6a‐KO) and wild‐type (WT) mice fed a control diet (18% protein) or a low‐protein diet (6% protein) for 9 days. The role of GPRC6A in mediating the effects of a high‐protein diet on body weight was investigated in GPRC6a‐KO and WT mice fed a control diet (18% protein) or a high‐protein diet (50% protein) for 5 weeks. Results A high‐protein diet reduced body weight gain and food intake compared with a control diet in both WT and GPRC6a‐KO mice. A low‐protein diet decreased body weight gain in GPRC6a‐KO mice. Conclusions GPRC6A was not necessary for the effects of a low‐ or high‐protein diet on body weight and likely does not play a role in protein‐induced satiety.
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.21083