Prognostic significance of survivin, β-catenin and p53 expression in urothelial carcinoma

Survivin, β-catenin, and p53 are well-known cell-cycle and apoptosis regulators of tumorigenesis. Urothelial carcinomas (UCs) are the most common of the human cancers. Compared to superficial tumors (Ta, CIS, or T1), invasive UCs are important with regard to recurrence, progression, and mortality. T...

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Published in:Biomolecules & biomedicine 2015-08, Vol.15 (4), p.7-14
Main Authors: Senol, Serkan, Yildirim, Asif, Ceyran, Bahar, Uruc, Fatih, Zemheri, Ebru, Ozkanli, Seyma, Akalin, Ibrahim, Ulus, Ismail, Caskurlu, Turhan, Aydin, Abdullah
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Apoptosis
Apoptosis Regulatory Proteins - genetics
beta Catenin - biosynthesis
beta Catenin - genetics
Biomarkers, Tumor - analysis
Cancer
Carcinoma
Disease Progression
Disease-Free Survival
Female
Humans
Immunohistochemistry
Inhibitor of Apoptosis Proteins - biosynthesis
Inhibitor of Apoptosis Proteins - genetics
Male
Medical research
Medicine, Experimental
Microarray Analysis
Middle Aged
Mortality
Neoplasm Grading
Neoplasm Recurrence, Local
Prognosis
Survival Analysis
Tumor proteins
Tumor Suppressor Protein p53 - biosynthesis
Tumor Suppressor Protein p53 - genetics
Urinary Bladder Neoplasms - metabolism
Urinary Bladder Neoplasms - mortality
Urologic Neoplasms - metabolism
Urologic Neoplasms - mortality
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Summary:Survivin, β-catenin, and p53 are well-known cell-cycle and apoptosis regulators of tumorigenesis. Urothelial carcinomas (UCs) are the most common of the human cancers. Compared to superficial tumors (Ta, CIS, or T1), invasive UCs are important with regard to recurrence, progression, and mortality. Therefore, we examined whether survivin, β-catenin, and p53 could be used as the biomarkers for the early prediction of the invasiveness of UCs and the overall survival of the patients. We investigated the prognostic expressions of those biomarkers in UC (n=147) and in non-muscle invasive UC (NMI-UC) (n=113), using tissue microarray and immunohistochemistry. Spearman's correlation analysis and multivariate Cox regression analyses were used for statistical interpretation. High expressions of β-catenin, survivin, and p53 were associated with a high T stage, recurrence, progression, mortality, low recurrence-free survival, low progression-free survival and low overall survival (p
ISSN:2831-0896
1512-8601
1840-4812
2831-090X
DOI:10.17305/bjbms.2015.556