Lymphatic Invasion is an Independent Adverse Prognostic Factor in Patients with Colorectal Liver Metastasis

Background For a selection of patients with colorectal liver metastases (CRLM), liver resection is a curative option. In order to predict long-term survival, clinicopathologic risk scores have been developed, but little is known about histologic factors and their prognostic value for disease-free an...

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Bibliographic Details
Published in:Annals of surgical oncology 2015-12, Vol.22 (Suppl 3), p.638-645
Main Authors: de Ridder, Jannemarie A. M., Knijn, Nikki, Wiering, Bastiaan, de Wilt, Johannes H. W., Nagtegaal, Iris D.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - metabolism
Colorectal Cancer
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Female
Follow-Up Studies
Hepatectomy
Humans
Immunoenzyme Techniques
Liver Neoplasms - secondary
Liver Neoplasms - surgery
Lymph Nodes - pathology
Lymphatic Metastasis
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local - metabolism
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - surgery
Neoplasm Staging
Oncology
Prognosis
Surgery
Surgical Oncology
Survival Rate
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Summary:Background For a selection of patients with colorectal liver metastases (CRLM), liver resection is a curative option. In order to predict long-term survival, clinicopathologic risk scores have been developed, but little is known about histologic factors and their prognostic value for disease-free and overall survival. The objective of the present study was to assess possible prognostic histologic factors in patients with solitary CRLM treated with liver resection who did not receive neoadjuvant treatment. Methods Patients with solitary CRLM who underwent liver resection between 1992 and 2011 were evaluated for clinical prognostic factors. Histologic analyses on tumor thickness at the tumor–normal interface, presence of a fibrotic capsule, intrahepatic vascular invasion, lymphatic invasion, or bile duct invasion and perineural growth were performed, using immunohistochemistry. Results A total of 124 patients were analyzed with a median follow-up of 41 months (range 1–232 months). There was no association between histologic factors and disease-free survival in multivariate analysis. In multivariate analysis, intrahepatic lymphatic invasion was associated with a decreased overall survival (41.9 vs. 61.0 months; p  = 0.041), especially in combination with vascular invasion ( n  = 15) (28.1 vs. 62.2 months; p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-015-4562-8