Influence of treatment center and hospital volume on survival for locally advanced cervical cancer

Abstract Objective Procedural volume is associated with outcomes for many surgical interventions. Little is known about the association between volume and outcomes of radiation. We examined the association between treatment center and hospital volume and outcomes for women with locally advanced cerv...

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Published in:Gynecologic oncology 2015-12, Vol.139 (3), p.506-512
Main Authors: Wright, Jason D, Huang, Yongmei, Ananth, Cande V, Tergas, Ana I, Duffy, Cassandra, Deutsch, Israel, Burke, William M, Hou, June Y, Neugut, Alfred I, Hershman, Dawn L
Format: Article
Language:English
Subjects:
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adenocarcinoma - therapy
Adult
Aged
Brachytherapy - statistics & numerical data
Cancer Care Facilities - statistics & numerical data
Carcinoma, Adenosquamous - mortality
Carcinoma, Adenosquamous - pathology
Carcinoma, Adenosquamous - therapy
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Cervical cancer
Chemoradiation
Chemosensitization
Female
Follow-Up Studies
Hematology, Oncology and Palliative Medicine
Hospitals, High-Volume - statistics & numerical data
Hospitals, Low-Volume - statistics & numerical data
Humans
Insurance, Health - statistics & numerical data
Middle Aged
Obstetrics and Gynecology
Outcomes
Radiation
Survival Rate
United States - epidemiology
Uterine Cervical Neoplasms - mortality
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - therapy
Volume
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Summary:Abstract Objective Procedural volume is associated with outcomes for many surgical interventions. Little is known about the association between volume and outcomes of radiation. We examined the association between treatment center and hospital volume and outcomes for women with locally advanced cervical cancer treated with radiation. Methods Women with stage IIB–IVA cervical cancer treated with primary radiation from 1998 to 2011 and recorded in the National Cancer Database were examined. Hospital volume was estimated as the mean annualized volume, while center-specific effects on care were examined using a hospital-specific random effect. Multivariable regression models adjusted for metrics of treatment quality were used to estimate survival. Results 20,766 patients treated at 1115 hospitals were identified. The median follow-up was 24.2 months while 5-year survival was 36.5% (95% CI, 35.6–37.4%). Higher hospital volume was associated with receipt of brachytherapy (P < 0.05), but had no effect on use of chemotherapy. In a multivariable model accounting for clinical and demographic factors as well as quality of care, hospital volume was not associated with survival (P = 0.25). The specific hospital in which patients received care was the strongest predictor of survival (P < 0.0001) followed by stage, year of diagnosis and treatment quality (P < 0.0001 for all). The hospital-specific effect on mortality expressed as a hazard ratio, ranged from 0.66 to 1.53 across hospitals. Conclusion For locally advanced cervical cancer, hospital volume has a minimal impact on outcome; however, the specific center in which care is delivered is strongly associated with survival.
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2015.07.015